Wang Chengran, Dong Tianqi, Rong Xin'ao, Yang Yuce, Mou Jianhui, Li Jiaqi, Ge Jianli, Mu Xupeng, Jiang Jinlan
Department of' Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, , 130033, Jilin Province, China.
Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, 130041, Jilin Province, China.
J Cancer Res Clin Oncol. 2025 May 31;151(6):178. doi: 10.1007/s00432-025-06187-w.
Prostate cancer (PCa) is a leading cause of cancer-related deaths in men, with the microbiome emerging as a significant factor in its development and progression. Understanding the microbiome's role could provide new insights into PCa pathogenesis and treatment.
This review aims to explore the interactions between the microbiome and PCa, focusing on microbial imbalances and their effects on immune responses, inflammation, and hormone levels. It also discusses advanced research techniques and the potential for microbiome modulation in PCa management.
The review synthesizes current literature on the microbiome's role in PCa, highlighting differences in microbial composition between cancerous and healthy prostate tissues. It examines techniques such as high-throughput sequencing and metagenomics and explores the mechanisms through which the microbiome influences PCa.
The review reveals substantial microbial differences in prostate tissues of PCa patients compared to healthy individuals, indicating a potential link between microbiome alterations and disease progression. It highlights the promise of microbiome-based strategies for diagnosis and treatment and underscores the need for further research into personalized, microbiome-centric approaches for PCa management.
前列腺癌（PCa）是男性癌症相关死亡的主要原因，微生物群已成为其发生和发展的重要因素。了解微生物群的作用可为前列腺癌的发病机制和治疗提供新的见解。
本综述旨在探讨微生物群与前列腺癌之间的相互作用，重点关注微生物失衡及其对免疫反应、炎症和激素水平的影响。它还讨论了先进的研究技术以及微生物群调节在前列腺癌管理中的潜力。
该综述综合了关于微生物群在前列腺癌中作用的当前文献，突出了癌性前列腺组织与健康前列腺组织之间微生物组成的差异。它研究了高通量测序和宏基因组学等技术，并探讨了微生物群影响前列腺癌的机制。
该综述揭示，与健康个体相比，前列腺癌患者的前列腺组织中存在大量微生物差异，表明微生物群改变与疾病进展之间存在潜在联系。它强调了基于微生物群的诊断和治疗策略的前景，并强调需要进一步研究以个性化、以微生物群为中心的方法来管理前列腺癌。
