Sweet M B, Schnitzler C M, Hough F S
S Afr Med J. 1987 Mar 7;71(5):317-9.
Femoral heads were resected from patients with Mseleni joint disease, and cartilage present in 'islands' on the articulating surfaces and over marginal osteophytes was removed for study. Some specimens were grown in short-term organ culture and labelled with sulphur-35. Proteoglycans present in the tissue, and newly synthesised macromolecules were extracted, purified and assessed. The results indicated that very few of the proteoglycans present or synthesised during culture were capable of aggregation with hyaluronate and that the average size of the macromolecules was smaller than normal. In addition a large proportion of the proteoglycans were very small in size and were thought to resemble a molecule found in immature articular cartilage. The response to degenerative disease was unusual and may be peculiar to the Mseleni condition.
从患有姆塞莱尼关节病的患者身上切除股骨头，并将关节表面“岛屿”状以及边缘骨赘上的软骨切除用于研究。一些标本进行了短期器官培养并用硫-35标记。提取、纯化并评估了组织中存在的蛋白聚糖以及新合成的大分子。结果表明，培养过程中存在或合成的蛋白聚糖中，很少有能够与透明质酸聚集的，并且大分子的平均尺寸小于正常水平。此外，很大一部分蛋白聚糖尺寸非常小，被认为类似于在未成熟关节软骨中发现的一种分子。对退行性疾病的反应不寻常，可能是姆塞莱尼病症所特有的。
