Analysis of Biomarkers and Marginal Bone Loss in Platform-Switched and Nonplatform-Switched Implants: A Randomized Clinical Trial.

OBJECTIVES

To compare the peri-implant crevicular fluid (PICF) biomarker levels, peri-implant status, and marginal bone level (MBL) differences of implants restored with randomly assigned nonplatform-switched (NPS) or platform-switched (PS) abutments.

METHODS

Ninety-four implants in 27 subjects were included in this study. Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), interleukin-1 (IL-1), monocyte chemotactic protein-1 (MCP-1) levels in PICF, peri-implant health, and the change in the MBL were evaluated at the time of restoration ( ) and after 12 months ( ).

RESULTS

The IL-1 levels decreased and the RANKL, OPG, and MCP-1 levels increased from to ( < 0.05) in both groups. RANKL/OPG ratio at , MCP-1 levels at , and the MCP-1 change from to were lower in the PS group than in the NPS group ( < 0.05). MBL change was lower (0.51 ± 0.31 mm) in the PS group than that (0.75 ± 0.29 mm) in the NPS group at ( < 0.001). Peri-implant health status between the study groups was negligible.

CONCLUSION

PS was superior to NPS regarding the preservation of MBL. Higher MCP-1 levels, altered RANKL/OPG ratio, and lower OPG levels in the NPS group could be associated with subclinical peri-implant bone remodeling.