Department of Academic Psychiatry, Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Royal North Shore Hospital, Sydney, NSW, Australia.
Molecular Imaging and Neuropathology Division, Department of Psychiatry, Columbia University, New York, NY, USA.
Lancet. 2018 Nov 24;392(10161):2299-2312. doi: 10.1016/S0140-6736(18)31948-2. Epub 2018 Nov 2.
Major depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030. In practice, its detection, diagnosis, and management often pose challenges for clinicians because of its various presentations, unpredictable course and prognosis, and variable response to treatment.
重度抑郁症是一种常见疾病，严重限制了社会心理功能，降低了生活质量。2008 年，世界卫生组织将重度抑郁症列为全球疾病负担的第三大病因，并预计到 2030 年该疾病将排名第一。在实践中，由于其各种表现、不可预测的病程和预后以及对治疗的不同反应，其检测、诊断和管理常常给临床医生带来挑战。
