乳腺原发性神经内分泌癌伴副肿瘤性血小板增多症；1例罕见病例报告
Primary neuroendocrine carcinoma of the breast with paraneoplastic thrombocytosis; a rare case report.
作者信息
Kherbek Haidara, Skef Jana, Kherbek Sara, Abdulrahman Seif-Aldin, Alshehabi Zuheir, Zahlouk Nadim
机构信息
Faculty of Medicine, Tishreen University, Latakia, Syria.
Department of Pathology, Cancer Research Center, Tishreen University, Latakia, Syria.
出版信息
Ann Med Surg (Lond). 2022 Apr 22;77:103664. doi: 10.1016/j.amsu.2022.103664. eCollection 2022 May.
INTRODUCTION
primary neuroendocrine cancer of the breast (NECB) is a very rare entity, comprising less than 0,1% of all breast tumors. It was first reported in 1977 by cubilla et al.
CASE PRESENTATION
we report the case of a 60-year-old rural Syrian female who admitted to our hospital due to a painless lump in her right breast. Radiological & clinical findings were highly indicative of breast carcinoma. Therefore, a partial biopsy was performed and microscopic examination suggested the diagnosis of neuroendocrine carcinoma of the breast, which was confirmed by immunohistochemical staining. Lab findings were also indicative for anemia & thrombocytosis.
CLINICAL DISCUSSION
neuroendocrine tumors are usually seen in the intestine & lungs. However, their presence as primary tumors in the breast is extremely rare.
CONCLUSION
our article demonstrates a challenging case of primary neuroendocrine breast carcinoma with paraneoplastic thrombocytosis, which clarifies the major diagnostic & therapeutic approaches used in its management.
引言
乳腺原发性神经内分泌癌（NECB）是一种非常罕见的疾病，占所有乳腺肿瘤的比例不到0.1%。它于1977年由库比利亚等人首次报道。
病例介绍
我们报告了一名60岁的叙利亚农村女性病例，她因右乳无痛性肿块入住我院。影像学和临床检查结果高度提示乳腺癌。因此，进行了部分活检，显微镜检查提示乳腺神经内分泌癌的诊断，免疫组化染色证实了这一诊断。实验室检查结果还提示贫血和血小板增多。
临床讨论
神经内分泌肿瘤通常见于肠道和肺部。然而，它们作为乳腺原发性肿瘤极为罕见。
结论
我们的文章展示了一例具有副肿瘤性血小板增多症的原发性神经内分泌乳腺癌的具有挑战性的病例，阐明了其治疗中使用的主要诊断和治疗方法。
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