Ju Husileng, Liu Ming
Department of Thyroid and Breast Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010059, P.R. China.
Oncol Lett. 2024 Nov 27;29(2):79. doi: 10.3892/ol.2024.14825. eCollection 2025 Feb.
Primary neuroendocrine neoplasm of the breast (PNENB) is a rare subtype of breast cancer, accounting for <1% of all breast tumors. The morphological features of PNENB are similar to those of neuroendocrine tumors originating in the lungs or gastrointestinal system, with tumor cells exhibiting the strong expression of neuroendocrine markers, including chromogranin A and synaptophysin. Since this type of cancer was first reported, the definition, classification and diagnostic criteria of PNENB have evolved and changed. However, accurate diagnostic criteria and standard treatment guidelines are lacking. The present report describes a specific case of PNENB, which was consistent with the morphological and molecular features of other cases in most previous studies. In addition, the current body of literature on PNENB, including its development, diagnosis, molecular features, treatment and prognosis is reviewed.
乳腺原发性神经内分泌肿瘤（PNENB）是乳腺癌的一种罕见亚型，占所有乳腺肿瘤的比例不到1%。PNENB的形态学特征与起源于肺或胃肠道系统的神经内分泌肿瘤相似，肿瘤细胞强烈表达神经内分泌标志物，包括嗜铬粒蛋白A和突触素。自首次报道这种癌症以来，PNENB的定义、分类和诊断标准不断演变和变化。然而，目前缺乏准确的诊断标准和标准化治疗指南。本报告描述了一例PNENB的具体病例，该病例在大多数先前研究中与其他病例的形态学和分子特征一致。此外，本文还对目前关于PNENB的文献进行了综述，包括其发展、诊断、分子特征、治疗和预后。
