Matsuura H, Ikeda Y, Imaya H, Nakazawa S
Surg Neurol. 1987 May;27(5):433-6. doi: 10.1016/0090-3019(87)90249-7.
Blood flow within tumors is important from the standpoint of malignant tumor chemotherapy. It is known that the degree of tissue penetration of lipid-soluble anticancer agents depends on the amount of blood flow within the brain tumor. We investigated regional cerebral blood flow in rats with brain tumors. As compared with that of normal brain, the blood flow within the tumor was low and became significantly increased by inducing a hypertensive condition. These data suggest that the combination of anticancer agent and hypertensive drug is of value to enhance the effects of chemotherapy of brain tumor.
从恶性肿瘤化疗的角度来看，肿瘤内的血流很重要。众所周知，脂溶性抗癌药物的组织渗透程度取决于脑肿瘤内的血流量。我们研究了患有脑肿瘤的大鼠的局部脑血流量。与正常脑相比，肿瘤内的血流量较低，并且通过诱导高血压状态会显著增加。这些数据表明，抗癌药物和降压药物联合使用对于增强脑肿瘤化疗效果具有价值。
