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Blood flow and metabolic microenvironment of brain tumors.

作者信息

Vaupel P

机构信息

Department of Physiology and Pathophysiology, University of Mainz, Germany.

出版信息

J Neurooncol. 1994;22(3):261-7. doi: 10.1007/BF01052931.

DOI:10.1007/BF01052931
PMID:7760105
Abstract
摘要

相似文献

1
Blood flow and metabolic microenvironment of brain tumors.脑肿瘤的血流与代谢微环境
J Neurooncol. 1994;22(3):261-7. doi: 10.1007/BF01052931.
2
[Evaluation of blood flow and metabolism in glioma using positron emission tomography].[利用正电子发射断层扫描评估胶质瘤中的血流和代谢]
No Shinkei Geka. 1993 May;21(5):389-94.
3
Vascular factors affecting drug delivery to brain tumors.影响药物向脑肿瘤递送的血管因素。
Basic Life Sci. 1989;50:115-20. doi: 10.1007/978-1-4684-5622-6_16.
4
Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.在脑微环境中维持胶质瘤侵袭和旁分泌生物学特性的自分泌因子。
J Natl Cancer Inst. 2007 Nov 7;99(21):1583-93. doi: 10.1093/jnci/djm187. Epub 2007 Oct 30.
5
Regional cerebral blood flow in various types of brain tumor. Effect of the space-occupying lesion on blood flow in brain tissue close to and remote from tumor site.
Acta Neurol Scand. 1982 Aug;66(2):160-71. doi: 10.1111/j.1600-0404.1982.tb04513.x.
6
High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas.高微血管血容量与人类胶质瘤中的高葡萄糖摄取及肿瘤血管生成相关。
Clin Cancer Res. 2000 Jun;6(6):2189-200.
7
Regional blood flow and blood-to-tissue transport in five brain tumor models. Implications for chemotherapy.
Prog Exp Tumor Res. 1984;27:132-53. doi: 10.1159/000408227.
8
Selective change of blood flow in experimental brain tumor with induced hypertension.诱导性高血压对实验性脑肿瘤血流的选择性改变
Surg Neurol. 1987 May;27(5):433-6. doi: 10.1016/0090-3019(87)90249-7.
9
Intracarotid recombinant human tumor necrosis factor-alpha reduces cerebral blood flow and methionine uptake in rat brain tumors.颈内动脉注射重组人肿瘤坏死因子-α可减少大鼠脑肿瘤的脑血流量和蛋氨酸摄取。
J Neurooncol. 1997 Sep;34(2):123-9. doi: 10.1023/a:1005781210974.
10
Tenascin-C expression in the cyst wall and fluid of human brain tumors correlates with angiogenesis.人脑肿瘤囊壁和囊液中肌腱蛋白-C的表达与血管生成相关。
Neurosurgery. 1997 Nov;41(5):1052-9. doi: 10.1097/00006123-199711000-00007.

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How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen-dependent pathologies.如何最好地解释组织中氧气水平的测量结果，使其成为癌症和其他依赖氧气的病理患者护理的有效临床工具。
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Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose.胶质母细胞瘤细胞的激酶组分析揭示磷脂酶Cγ1（PLCG1）是低糖环境下的一个靶点。
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Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts.

本文引用的文献

1
Heterogeneity and stability of local PO2 distribution within the brain tissue.脑组织内局部氧分压分布的异质性和稳定性。
Adv Exp Med Biol. 1994;345:567-74. doi: 10.1007/978-1-4615-2468-7_75.
2
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.人体恶性脑肿瘤中氧分压分布和生物还原酶的直接测量
Int J Radiat Oncol Biol Phys. 1994 Jun 15;29(3):427-31. doi: 10.1016/0360-3016(94)90432-4.
3
Regional blood flow, capillary permeability, and glucose utilization in two brain tumor models: preliminary observations and pharmacokinetic implications.
应激反应导致胶质母细胞瘤耐药——创新性放疗（iRT）概念的必要性。
Cancers (Basel). 2016 Jan 13;8(1):15. doi: 10.3390/cancers8010015.
4
Response to commentary by Champ and Klement: Is a ketogenic diet the solution for the hyperglycemia problem in glioblastoma therapy?对尚普和克莱门特评论的回应：生酮饮食是胶质母细胞瘤治疗中高血糖问题的解决方案吗？
Strahlenther Onkol. 2015 Mar;191(3):283-4. doi: 10.1007/s00066-014-0793-z.
5
Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance.异常血管生成在肿瘤缺氧的发展及其相关放射抵抗中的关键作用。
Cancers (Basel). 2014 Apr 8;6(2):813-28. doi: 10.3390/cancers6020813.
6
Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.用于治疗恶性脑肿瘤的有效全身化疗的研发进展。
J Transl Med. 2009 Sep 1;7:77. doi: 10.1186/1479-5876-7-77.
7
[Perfusion measurement using the T2* contrast media dynamics in neuro-oncology. Physical basics and clinical applications].[利用T2*造影剂动力学在神经肿瘤学中进行灌注测量。物理基础与临床应用]
Radiologe. 2005 Jul;45(7):618-32. doi: 10.1007/s00117-004-1048-2.
8
[Noninvasive measurement of relative cerebral blood flow with the blood bolus MRI arterial spin labeling: basic physics and clinical applications].[基于血团磁共振动脉自旋标记的相对脑血流无创测量：基础物理学与临床应用]
Radiologe. 2004 Feb;44(2):164-73. doi: 10.1007/s00117-003-0941-4.
9
Antiangiogenic therapy in brain tumor models.脑肿瘤模型中的抗血管生成疗法。
J Neurooncol. 1999;45(3):247-55. doi: 10.1023/a:1006395802727.
10
Positron emission tomography in patients with primary CNS lymphomas.原发性中枢神经系统淋巴瘤患者的正电子发射断层扫描
J Neurooncol. 1999 Jul;43(3):231-6. doi: 10.1023/a:1006202402010.
两种脑肿瘤模型中的局部脑血流量、毛细血管通透性及葡萄糖利用：初步观察结果及药代动力学意义
Cancer Treat Rep. 1981;65 Suppl 2:3-12.
4
Local cerebral blood flow and glucose consumption of rats with experimental gliomas.
J Cereb Blood Flow Metab. 1982;2(1):25-32. doi: 10.1038/jcbfm.1982.3.
5
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes.用pH微电极测量BDIX大鼠移植神经肿瘤和正常组织中的pH分布。
Cancer Res. 1982 Apr;42(4):1498-504.
6
Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography.通过[18F]氟脱氧葡萄糖和正电子发射断层扫描测量脑胶质瘤的葡萄糖利用情况。
Neurology. 1982 Dec;32(12):1323-9. doi: 10.1212/wnl.32.12.1323.
7
Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.进行中的工作：[18F]氟脱氧葡萄糖与正电子发射断层扫描在脑放射性坏死评估中的应用
Radiology. 1982 Sep;144(4):885-9. doi: 10.1148/radiology.144.4.6981123.
8
Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: analytical techniques and preliminary results.使用15O和正电子发射断层扫描技术测量脑肿瘤患者局部脑血流量和氧利用率：分析技术及初步结果
Neuroradiology. 1982;23(2):63-74. doi: 10.1007/BF00367239.
9
Effects of stroke on local cerebral metabolism and perfusion: mapping by emission computed tomography of 18FDG and 13NH3.
Ann Neurol. 1980 Jul;8(1):47-60. doi: 10.1002/ana.410080108.
10
Noninvasive determination of local cerebral metabolic rate of glucose in man.人体局部脑葡萄糖代谢率的无创测定
Am J Physiol. 1980 Jan;238(1):E69-82. doi: 10.1152/ajpendo.1980.238.1.E69.