Suslov A P, Riabykh T P, Slavina E G, Kasatkina N N, Leĭpunskaia I L
Tsitologiia. 1987 Jan;29(1):79-85.
A study was made of the mouse life span in relation to the time of tumor cell injection on an hourly basis, while the carcinogenic effect was studied in relation to the time of urethan injection. Changes in both the values were shown to vary with ultradian rhythms. It was found that natural killer cell activity against tumor cells, migration index of normal spleen cells in the presence of tumor cells and the activity of carcinogen-metabolising enzyme system of intact animals also exhibited ultradian oscillations. It is assumed that oscillations of natural resistance against transplantable or chemically-induced tumor may be due to the changes of these parameters.
以小时为单位研究了小鼠寿命与肿瘤细胞注射时间的关系，同时研究了致癌作用与乌拉坦注射时间的关系。结果表明，这两个数值的变化均随超日节律而变化。研究发现，针对肿瘤细胞的自然杀伤细胞活性、肿瘤细胞存在时正常脾细胞的迁移指数以及完整动物的致癌物代谢酶系统活性也呈现超日振荡。据推测，对可移植或化学诱导肿瘤的自然抵抗力的振荡可能是由于这些参数的变化所致。
