The First Clinical College, 74738Shandong Chinese Medical University, Ji Nan, People's Republic of China.
Department of Pulmonary and Critical Care Medicine, 159393The First Affiliated Hospital of Shandong Chinese Medical University, Ji Nan, People's Republic of China.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221103867. doi: 10.1177/10760296221103867.
Acute pulmonary embolism (APE) is a typical cardiovascular emergency worldwide. Mean hemoglobin concentration (MCHC) is a standard indicator of anemia. Studies on the association between MCHC and APE are scarce. We aimed to investigate the relationship between MCHC and APE.
Clinical data were extracted from the Medical Information Bank for Intensive Care (MIMIC)-III. Adult (≥18 years) patients with APE admitted for the first time were included in this study. An analysis was conducted to evaluate the association between MCHC and the prognosis of patients by the Cox regression analysis, generalized additives models and Kaplan-Meier survival curves. The primary outcome was 30-day mortality, and the secondary outcomes were 1-year and 3-year mortality.
A total of 813 patients who met the selection criteria were enrolled, of whom 130 (16.0%) died within 30 days of admission. Univariate Cox regression indicated that MCHC was significantly associated with mortality (30-day: HR = 0.74, 95% CI = 0.66-0.82, < 0.001; 1-year: HR = 0.80, 95% CI = 0.74-0.86, < 0.001; 3-year: HR = 0.82, 95% CI = 0.77-0.88, < 0.001). MCHC remains stable after adjusting multiple models. Kaplan-Meier survival curves showed that patients with lower MCHC had a poorer 30-day prognosis.
Lower MCHC is an independent risk factor for increased mortality in patients with APE. As an inexpensive biomarker, MCHC should receive more attention.
急性肺栓塞（APE）是全球范围内一种典型的心血管急症。平均血红蛋白浓度（MCHC）是贫血的标准指标。关于 MCHC 与 APE 之间关系的研究较少。本研究旨在探讨 MCHC 与 APE 之间的关系。
从医疗信息库-强化治疗版（MIMIC-III）中提取临床数据。纳入首次因 APE 住院的成年（≥18 岁）患者。通过 Cox 回归分析、广义加性模型和 Kaplan-Meier 生存曲线评估 MCHC 与患者预后之间的关系。主要结局为 30 天死亡率，次要结局为 1 年和 3 年死亡率。
共纳入 813 名符合入选标准的患者，其中 130 名（16.0%）患者在入院后 30 天内死亡。单因素 Cox 回归分析表明，MCHC 与死亡率显著相关（30 天：HR=0.74，95%CI=0.66-0.82， < 0.001；1 年：HR=0.80，95%CI=0.74-0.86， < 0.001；3 年：HR=0.82，95%CI=0.77-0.88， < 0.001）。在调整多个模型后，MCHC 仍保持稳定。Kaplan-Meier 生存曲线显示，MCHC 较低的患者 30 天预后较差。
较低的 MCHC 是 APE 患者死亡率增加的独立危险因素。作为一种廉价的生物标志物，MCHC 应受到更多关注。
