Peng You-Fan, Zhang Qing-Song, Luo Wei-Gui
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, People's Republic of China.
Int J Gen Med. 2023 Jul 27;16:3171-3177. doi: 10.2147/IJGM.S417962. eCollection 2023.
We investigated the clinical usefulness of mean corpuscular hemoglobin concentration (MCHC) in patients with pneumoconiosis.
We retrospectively investigated the medical records from 52 patients with pneumoconiosis, and erythrocyte parameters were analyzed in pneumoconiosis patients with different stages.
Here, we found that the values of MCHC were significantly lower in III stage pneumoconiosis than those with I/II stage (p = 0.024), and there was no significantly difference in MCHC between smoking pneumoconiosis patients and non-smoking pneumoconiosis patients. A negatively correlation between MCHC and disease stage was observed in patients with pneumoconiosis (r = -0.298, p = 0.032). In multiple linear regression analysis, the MCHC was found to be independently associated with advanced pneumoconiosis in patients with pneumoconiosis (p=0.011). The results of logistic regression analysis indicated that decreased MCHC was an independent risk factor of advanced pneumoconiosis in patients with pneumoconiosis (OR: 0.936, CI95%: 0.877-0.999, p = 0.046). Receiver operating characteristic curve analysis showed that the optimal cutoff value of MCHC was 330 g/L to identify advanced pneumoconiosis with the area under the curve of 0.694 (CI95%:0.550-0.839, p = 0.018).
The decreased MCHC is associated with advanced pneumoconiosis, and MCHC may be used as a monitoring marker for follow-up of pneumoconiosis patients.
我们研究了平均红细胞血红蛋白浓度（MCHC）在尘肺病患者中的临床应用价值。
我们回顾性调查了52例尘肺病患者的病历，并对不同阶段的尘肺病患者的红细胞参数进行了分析。
我们发现，Ⅲ期尘肺病患者的MCHC值显著低于Ⅰ/Ⅱ期患者（p = 0.024），吸烟尘肺病患者与不吸烟尘肺病患者的MCHC无显著差异。尘肺病患者中观察到MCHC与疾病阶段呈负相关（r = -0.298，p = 0.032）。在多元线性回归分析中，发现MCHC与尘肺病患者的晚期尘肺病独立相关（p = 0.011）。逻辑回归分析结果表明，MCHC降低是尘肺病患者晚期尘肺病的独立危险因素（OR：0.936，CI95%：0.877 - 0.999，p = 0.046）。受试者工作特征曲线分析表明，MCHC的最佳截断值为330 g/L，用于识别晚期尘肺病，曲线下面积为0.694（CI95%：0.550 - 0.839，p = 0.018）。
MCHC降低与晚期尘肺病相关，MCHC可作为尘肺病患者随访的监测指标。
