Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.
Ruibiao (Wuhan) Biotechnology Co. Ltd, Wuhan, China.
Sci Rep. 2020 Dec 3;10(1):21185. doi: 10.1038/s41598-020-78321-2.
The red cell distribution width (RDW) has been reported to be positively correlated with short-term mortality of pulmonary disease in adults. However, it is not clear whether RDW was associated with the long-term prognosis for acute respiratory failure (ARF). Thus, an analysis was conducted to evaluate the association between RDW and 3-year mortality of patients by the Cox regression analysis, generalized additives models, subgroup analysis and Kaplan-Meier analysis. A total of 2999 patients who were first admitted to hospital with ARF were extracted from the Medical Information Mart for Intensive Care III database (MIMIC-III). The Cox regression analysis showed that the high RDW was associated with 3-year mortality (HR 1.10, 95% CI 1.07, 1.12, P < 0.0001) after adjusting for age, gender, ethnicity and even co-morbid conditions. The ROC curve illustrated the AUC of RDW was 0.651 (95% CI 0.631, 0.670) for prediction of 3-year mortality. Therefore, there is an association between the RDW and survival time of 3 years follow-up, particularly a high RDW on admission was associated with an increased risk of long-term mortality in patients with ARF. RDW may provide an alternative indicator to predict the prognosis and disease progression and more it is easy to get.
红细胞分布宽度（RDW）已被报道与成人肺部疾病的短期死亡率呈正相关。然而，RDW 是否与急性呼吸衰竭（ARF）的长期预后相关尚不清楚。因此，通过 Cox 回归分析、广义加法模型、亚组分析和 Kaplan-Meier 分析，对 RDW 与 3 年死亡率之间的关系进行了分析。从 MIMIC-III 数据库中提取了 2999 名首次因 ARF 住院的患者，进行 Cox 回归分析显示，在校正年龄、性别、种族甚至合并症等因素后，高 RDW 与 3 年死亡率相关（HR 1.10，95%CI 1.07，1.12，P<0.0001）。ROC 曲线表明 RDW 预测 3 年死亡率的 AUC 为 0.651（95%CI 0.631，0.670）。因此，RDW 与 3 年随访的生存时间之间存在关联，特别是入院时的高 RDW 与 ARF 患者的长期死亡率增加相关。RDW 可能提供了一种替代指标来预测预后和疾病进展，而且它更容易获得。
