Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
Dalton Trans. 2022 Jun 13;51(23):8938-8944. doi: 10.1039/d2dt01039a.
Cancer is still one of the most life-threatening diseases in the world. Among the various cancer therapeutic strategies, photothermal therapy (PTT) has attracted considerable attention due to its high treatment efficacy, low invasive burden, and minor side effects. Microporous metal-organic frameworks (MOFs) are potential materials for photothermal tumor treatment thanks to their high surface areas, suitable pore geometry, and easy functionalization. Through designating organic linkers, encapsulating PTT agents and fabricating MOF hybrids, MOF-based treatment platforms have great potential in PTT. In this review, we mainly summarize the recent advances of MOFs in photothermal combined cancer therapy. The present challenges and possible future prospects in this field are also explored.
癌症仍然是世界上最具威胁生命的疾病之一。在各种癌症治疗策略中，光热疗法（PTT）由于其高效的治疗效果、低侵入性负担和较小的副作用而引起了相当大的关注。微孔金属-有机骨架（MOFs）由于其高表面积、合适的孔几何形状和易于功能化，是光热肿瘤治疗的潜在材料。通过设计有机配体、封装 PTT 试剂和制造 MOF 杂化物，基于 MOF 的治疗平台在 PTT 中具有很大的潜力。在这篇综述中，我们主要总结了 MOFs 在光热联合癌症治疗中的最新进展。还探讨了该领域目前面临的挑战和可能的未来前景。
