Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 210009, P. R. China.
Department of Endodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang, Nanjing 210008, P. R. China.
J Mater Chem B. 2021 May 12;9(18):3756-3777. doi: 10.1039/d1tb00349f.
Metal-Organic Frameworks (MOFs) are constructed from metal ions/cluster nodes and functional organic ligands through coordination bonds. Owing to the advantages of diverse synthetic methods, easy modification after synthesis, large adsorption capacity for heavy metals, and short equilibrium time, considerable attention has recently been paid to MOFs for tumor phototherapy. Through rational tuning of metal ions and ligands, MOFs present abundant properties for various applications. Light-triggered phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is an emerging cancer treatment approach. Nanosized MOFs can be applied as phototherapeutic agents to accomplish phototherapy with excellent phototherapeutic efficacy. This review outlines the latest advances in the field of phototherapy with various metal ion-based MOFs.
金属-有机框架（MOFs）是通过配位键由金属离子/簇节点和功能有机配体构建而成的。由于具有多种合成方法的优势、合成后易于修饰、对重金属具有较大的吸附容量以及平衡时间短等优点，MOFs 在肿瘤光疗方面引起了广泛关注。通过对金属离子和配体的合理调节，MOFs 表现出了丰富的性能，可应用于各种领域。光触发的光疗，包括光动力疗法（PDT）和光热疗法（PTT），是一种新兴的癌症治疗方法。纳米级 MOFs 可用作光疗剂，以实现具有优异光疗效果的光疗。本综述概述了基于各种金属离子的 MOFs 的光疗领域的最新进展。
