CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Center of Conservation Biology, Core Botanical Gardens, Chinese Academy of Sciences, Wuhan, 430074, China; Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Department of Biology, University of Copenhagen, Copenhagen, 101165, Denmark.
J Ethnopharmacol. 2022 Sep 15;295:115404. doi: 10.1016/j.jep.2022.115404. Epub 2022 May 26.
Medicinal plants have been extensively used to treat various illnesses since the dawn of civilization. The genus Didymorcapus Wall. comprises 100 species widely distributed in the tropical regions of Asia, with a few found scattered in Africa and Australia. Species in this genus have long been used in folk medicine to treat various illnesses, including wounds, kidney stones, inflammations, asthma, flu, eczema, dysentery, fractures, colic etc. Some species have applications as weight loss agents, laxatives, and protective medication after childbirth.
To provide comprehensive information on the current knowledge of the ethnobotanical uses, phytochemical compounds, pharmacological applications, and toxicology of genus Didymocarpus to reveal its therapeutic potential, offering insights into future research opportunities.
Data were systematically obtained from books and online databases such as PubMed, Web of Science, Scopus, Sci Finder, Google Scholar, Science direct, ACS Publications, Elsevier, Wiley Online Library.
Seventeen Didymocarpus species have applications in traditional medicine in different Asian countries. A total of 166 compounds have been isolated from the genus Didymocarpus including terpenoids, flavonoids, phenolic compounds, fatty acids, chalcones, steroids, and others. Among these constituents, terpenoids, flavonoids, chalcones, and phenolics are the significant contributors to pharmacological activities of the genus Didymocarpus, possessing wide-reaching biological activities both in vivo and in vitro. The crude extracts and isolated phytochemical compounds from this genus have been shown to exhibit various pharmacological activities, including antiurolithiatic, nephro-protective, antimicrobial, anticancer, antidiabetic, cytotoxic, wound healing, and antioxidant activities.
Traditional uses and scientific evaluation of Didymocarpus indicate that Didymocarpus pedicellata is one of the most widely used species in some parts of the world. Although substantial progress on the chemical and pharmacological properties of Didymocarpus species has been made, further studies on the pharmacology and toxicology of these species are needed to ensure safety, efficacy, and quality. Also, further research on the structure-activity relationship of some of the isolated phytocompounds may improve their biological potency and scientific exploitation of traditional uses of the Didymocarpus taxa.
自文明起源以来，药用植物就被广泛用于治疗各种疾病。Didymorcapus Wall. 属包含 100 种，广泛分布于亚洲热带地区，少数种分布于非洲和澳大利亚。该属的物种长期以来一直被民间医学用于治疗各种疾病，包括伤口、肾结石、炎症、哮喘、流感、湿疹、痢疾、骨折、绞痛等。一些物种被用作减肥药、泻药和产后保护药物。
提供有关 Didymocarpus 属的民族植物学用途、植物化学化合物、药理学应用和毒理学的综合信息，揭示其治疗潜力，为未来的研究机会提供思路。
数据从书籍和在线数据库（如 PubMed、Web of Science、Scopus、Sci Finder、Google Scholar、Science direct、ACS Publications、Elsevier、Wiley Online Library）中系统地收集。
17 种 Didymocarpus 物种在不同的亚洲国家有传统医学应用。从该属中总共分离出 166 种化合物，包括萜类、类黄酮、酚类化合物、脂肪酸、查尔酮、甾体等。在这些成分中，萜类、类黄酮、查尔酮和酚类化合物是该属药理活性的重要贡献者，具有广泛的体内和体外生物活性。该属的粗提取物和分离的植物化学化合物已被证明具有多种药理活性，包括抗尿石症、肾保护、抗菌、抗癌、抗糖尿病、细胞毒性、伤口愈合和抗氧化活性。
对 Didymocarpus 的传统用途和科学评价表明，Didymocarpus pedicellata 是世界上某些地区使用最广泛的物种之一。尽管对 Didymocarpus 物种的化学和药理学特性已经取得了相当大的进展，但仍需要对这些物种的药理学和毒理学进行进一步研究，以确保安全性、有效性和质量。此外，对一些分离的植物化合物的结构-活性关系的进一步研究可能会提高它们的生物学效力，并促进对 Didymocarpus 类群传统用途的科学开发。
