Li Jun, Jiang Xiaohua, Li Caihua, Che Huihui, Ling Lin, Wei Zhaolian
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Clin Proteomics. 2022 May 28;19(1):19. doi: 10.1186/s12014-022-09353-1.
Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometrial receptivity of patients with polycystic ovary syndrome (PCOS) is known, understanding of endometrial receptivity is limited. A proteomics study in three patients with PCOS and 3 fertile women was performed to understand the impaired endometrial receptivity in patients with PCOS during luteal phases. Through isobaric tags for relative and absolute quantitation (iTRAQ) analyses, we identified 232 unique proteins involved in the metabolism, inflammation, and cell adhesion molecules. Finally, our results suggested that energy metabolism can affect embryo implantation, whereas inflammation and cell adhesion molecules can affect both endometrial conversion and receptivity. Our results showed that endometrial receptive damage in patients with PCOS is not a single factor. It is caused by many proteins, pathways, systems, and abnormalities, which interact with each other and make endometrial receptive research more difficult.
胚胎着床是一个复杂的发育过程，需要胚胎、子宫内膜以及子宫内膜因子微环境之间的协同相互作用。尽管多囊卵巢综合征（PCOS）患者的子宫内膜容受性受损是已知的，但对子宫内膜容受性的了解仍然有限。进行了一项蛋白质组学研究，纳入了3例PCOS患者和3例有生育能力的女性，以了解PCOS患者黄体期子宫内膜容受性受损的情况。通过相对和绝对定量同位素标记（iTRAQ）分析，我们鉴定出232种参与代谢、炎症和细胞粘附分子的独特蛋白质。最后，我们的结果表明能量代谢可影响胚胎着床，而炎症和细胞粘附分子可影响子宫内膜转化和容受性。我们的结果显示，PCOS患者的子宫内膜容受性损伤并非单一因素所致。它是由许多蛋白质、信号通路、系统及异常情况相互作用引起的，这使得子宫内膜容受性的研究更加困难。
