Institute of Vegetables and Flowers, Shandong Key Laboratory of Greenhouse Vegetable Biology, Shandong Branch of National Vegetable Improvement Center, Huanghuai Region Vegetable Scientific Station of Ministry of Agriculture(Shandong), Shandong Academy of Agricultural Sciences, Jinan, China.
College of Life Science, Shandong Normal University, Jinan, China.
Plant Signal Behav. 2020;15(2):1719312. doi: 10.1080/15592324.2020.1719312. Epub 2020 Jan 27.
Mitochondrial pyruvate carrier (MPC), which transports pyruvate into mitochondria, is a key regulatory element in the material metabolism and energy metabolism. Since MPC was firstly identified in yeast in 2012, many groups have investigated the function of MPC. As MPC is a classic material transporter, the focus of previous studies has been placed on its role in pyruvate transport. In this study, we discovered a novel Cd resistant gene, stress-seventy subfamily A 4 (SSA4), which can recover the Cd sensitive phenotype in the yeast mutant strain. It is suggested that, except for adjusting metabolism, MPC can regulate stress tolerance by regulating downstream genes in yeast. Previously, we discovered a Cd related gene, AGP30, which is associated with MPC1 in . These results indicate that MPC can regulate Cd tolerance through downstream genes in both and yeast. This study will pave the way for further exploring the bypass pathways of MPC at the molecular level, and the interaction between MPC and the downstream genes in biology.
线粒体丙酮酸载体（MPC）将丙酮酸转运到线粒体中，是物质代谢和能量代谢的关键调节因子。自 2012 年首次在酵母中鉴定出 MPC 以来，许多研究小组已经研究了 MPC 的功能。由于 MPC 是一种经典的物质转运体，因此之前的研究重点一直放在其在丙酮酸转运中的作用上。在这项研究中，我们发现了一个新的 Cd 抗性基因，应激 70 亚家族 A4（SSA4），它可以恢复酵母突变株的 Cd 敏感表型。这表明，除了调节代谢外，MPC 还可以通过调节酵母中的下游基因来调节应激耐受性。此前，我们发现了一个与 MPC1 相关的 Cd 相关基因，AGP30。这些结果表明，MPC 可以通过 和酵母中的下游基因来调节 Cd 耐受性。这项研究将为进一步探索 MPC 在分子水平上的旁路途径以及 MPC 与下游基因在生物学中的相互作用铺平道路。
