Department of IVF and Research, P. D. Hinduja Hospital and Medical Research Centre, Mumbai, 400016, India.
Mol Biol Rep. 2022 Feb;49(2):1519-1528. doi: 10.1007/s11033-021-06976-9. Epub 2022 Jan 6.
Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder commonly affecting the reproductive capacity of women leading to infertility. PCOS-related infertility is majorly due to anovulation; however, it is not the only cause. The defective endometrium causing recurrent miscarriage and implantation failure can also be accountable for infertility in PCOS women. The unusual levels of hormones and their receptors in the PCOS endometrium have a hostile effect during WOI, making the microenvironment unfavorable for embryo implantation. To date, many studies have been performed to determine the role of candidate genes in endometrial receptivity but very limited data is available using whole genome approach. This review aims at summarizing the existing studies on the basic aspects of endometrial receptivity in PCOS. The review focuses on aberrant levels of hormones and their receptors in the endometrium, affecting the receptivity. Additionally, it explores the novel approach reviewing the effect on treatment options administered for ovulation induction in PCOS on their endometrial receptivity. Overall, this review will help us to understand the molecular milieu in PCOS endometrium and its effect on the receptivity potential. However, to have a thorough understanding of the mechanistic approach of hormonal imbalance in PCOS on endometrial receptivity, there is a need to give more weightage to genome-wide studies in the future. The current review will further guide us to formulate future studies using whole genome technologies for the assessment of endometrial receptivity in different cohorts of PCOS women, which may have future diagnostic implementations.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，常影响女性的生殖能力导致不孕。PCOS 相关的不孕主要是由于排卵障碍引起的；然而，这并不是唯一的原因。反复流产和着床失败的缺陷子宫内膜也可能是 PCOS 女性不孕的原因。PCOS 子宫内膜中异常的激素水平及其受体在 WOI 期间产生了不良影响，使微环境不利于胚胎着床。迄今为止，已经进行了许多研究来确定候选基因在子宫内膜容受性中的作用，但使用全基因组方法的相关数据非常有限。本综述旨在总结 PCOS 子宫内膜容受性的现有研究的基本方面。该综述重点介绍了子宫内膜中激素及其受体水平的异常，影响了子宫内膜的容受性。此外，还探讨了一种新的方法，即综述 PCOS 患者排卵诱导治疗对其子宫内膜容受性的影响。总的来说，这篇综述将帮助我们了解 PCOS 子宫内膜的分子环境及其对容受性的影响。然而，为了更深入地了解 PCOS 中激素失衡对子宫内膜容受性的机制作用，未来需要更多地关注全基因组研究。本综述将进一步指导我们使用全基因组技术对不同 PCOS 女性队列的子宫内膜容受性进行未来的研究，这可能具有未来的诊断应用。
