斯皮茨肿瘤的概念演变与当前诊疗方法

Urso Carmelo, De Giorgi Vincenzo, Massi Daniela

Dermatopathology Study Center of Florence, 50129 Florence, Italy.

Dermatology Unit, Azienda USL Toscana Centro, and Section of Dermatology, Department of Health Sciences, University of Florence, 50122 Florence, Italy.

Dermatopathology (Basel). 2022 Apr 26;9(2):136-142. doi: 10.3390/dermatopathology9020017.

Over the past several decades, the study of Spitz neoplasms has flourished, with expanded conceptualization and refined terminology, providing a framework for the assessment and classification of Spitz nevi, atypical Spitz Tumors, and Spitz melanoma. Cancer genomics have generated concepts such as driver and passenger genes and clonal evolution, which can be applied to Spitz tumors. Herein, we provide a historical perspective, followed by a summary of current knowledge and clinical approaches for these challenging tumors.

在过去几十年里，对斯皮茨肿瘤的研究蓬勃发展，概念不断拓展，术语日益精确，为斯皮茨痣、非典型斯皮茨肿瘤和斯皮茨黑色素瘤的评估与分类提供了框架。癌症基因组学催生了驱动基因和乘客基因以及克隆进化等概念，这些概念可应用于斯皮茨肿瘤。在此，我们先提供一个历史视角，随后总结这些具有挑战性的肿瘤的当前知识和临床方法。