Zhou Zi-Wei, Long Hui-Zhi, Xu Shuo-Guo, Li Feng-Jiao, Cheng Yan, Luo Hong-Yu, Gao Li-Chen
School of Pharmacy, University of South China, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Changsha, China.
Front Pharmacol. 2022 May 13;13:899208. doi: 10.3389/fphar.2022.899208. eCollection 2022.
Inflammation is a protective response of the body to an irritant. When an inflammatory response occurs, immune cells are recruited to the injury, eliminating the irritation. The excessive inflammatory response can cause harm to the organism. Inflammation has been found to contribute to cervical cancer if there is a problem with the regulation of inflammatory response. Cervical cancer is one of the most common malignant tumors globally, and the incidence tends to be younger. The harm of cervical cancer cannot be ignored. The standard treatments for cervical cancer include surgery, radiotherapy and chemotherapy. However, the prognosis for this treatment is poor, so it is urgent to find a safer and more effective treatment. Natural products are considered excellent candidates for the treatment of cervical cancer. In this review, we first describe the mechanisms by which inflammation induces cervical cancer. Subsequently, we highlight natural products that can treat cervical cancer through inflammatory pathways. We also introduce natural products for the treatment of cervical cancer in clinical trials. Finally, methods to improve the anticancer properties of natural products were added, and the development status of natural products was discussed.
炎症是机体对刺激物的一种保护性反应。当发生炎症反应时，免疫细胞会被募集到损伤部位，消除刺激因素。过度的炎症反应会对机体造成损害。如果炎症反应调节出现问题，已发现炎症会导致宫颈癌。宫颈癌是全球最常见的恶性肿瘤之一，且发病有年轻化趋势。宫颈癌的危害不容忽视。宫颈癌的标准治疗方法包括手术、放疗和化疗。然而，这种治疗的预后较差，因此迫切需要找到更安全、更有效的治疗方法。天然产物被认为是治疗宫颈癌的优秀候选物。在本综述中，我们首先描述炎症诱导宫颈癌的机制。随后，我们重点介绍可通过炎症途径治疗宫颈癌的天然产物。我们还介绍了正在进行临床试验的用于治疗宫颈癌的天然产物。最后，补充了提高天然产物抗癌特性的方法，并讨论了天然产物的发展现状。
