Zhang Yuzhong, Chen Zichen, Zhao Huandi, Shen Jiali, Zhong Bo, Wu Qiong, Yang Jun, Jin Yulian, Zhang Qing, Ren Pengyu
Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Otorhinolaryngology, Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Neurol. 2022 May 11;13:881682. doi: 10.3389/fneur.2022.881682. eCollection 2022.
To define the normal values and examine the influence of aging on B81 bone vibrator-induced cervical vestibular-evoked myogenic potentials (B81-cVEMPs) and ocular vestibular-evoked myogenic potentials (B81-oVEMPs).
Seventy healthy subjects, divided into seven groups according to their ages, were enrolled in this study. The 4-9-, 10-19-, 20-29-, 30-39-, 40-49-, 50-59-, and 60-70-year-old participants were divided into groups I-VII, respectively. B81-cVEMP and B81-oVEMP were recorded in each group.
The B81-cVEMP response rates for groups I-VII were 100, 100, 100, 100, 95, 95, and 75%, respectively, with significant differences only between groups I-VI and group VII ( = 0.047, < 0.05). The B81-oVEMP response rates for groups I-VII were 100, 100, 100, 100, 70, 65, and 40%, respectively, with significant differences only between groups I-IV and groups V-VII ( = 0.020, = 0.008, = 0.000; < 0.05). The threshold, P13, and N23 latencies of B81-cVEMP positively correlated with age (r = 0.756, = 0.000; r = 0.357, = 0.003; r = 0.316, = 0.009; < 0.05). The raw amplitudes and corrected amplitudes negatively correlated with age (r = -0.641, = 0.000; r = -0.609, = 0.000, < 0.05). For B81-oVEMP, the corrected amplitudes negatively correlated with age (r = -0.638, = 0.000, <0.05), but the threshold and N10 latency positively correlated with age (r = 0.768, = 0.000; r = 0.334, = 0.009, < 0.05). Moreover, the interaural asymmetry ratio did not significantly correlate with age for B81-cVEMP and B81-oVEMP.
As age increased, the B81-cVEMP response rate decreased, the thresholds increased, P13 and N23 latencies were prolonged, and the raw amplitude and corrected amplitude decreased. The B81-oVEMP response rate and corrected amplitude decreased, the thresholds increased, and N10 latency was prolonged with age. These changes are probably due to the occurrence of morphological and functional changes in the vestibular system with aging. Therefore, we suggest establishing different reference values according to different age groups when evaluating the VEMP results in patients with vestibular diseases.
确定正常数值，并研究衰老对B81骨振动器诱发的颈肌前庭诱发肌源性电位（B81-cVEMPs）和眼肌前庭诱发肌源性电位（B81-oVEMPs）的影响。
本研究纳入70名健康受试者，根据年龄分为七组。4-9岁、10-19岁、20-29岁、30-39岁、40-49岁、50-59岁和60-70岁的参与者分别分为I-VII组。记录每组的B81-cVEMP和B81-oVEMP。
I-VII组的B81-cVEMP反应率分别为100%、100%、100%、100%、95%、95%和75%，仅I-VI组与VII组之间存在显著差异（P = 0.047，P<0.05）。I-VII组的B81-oVEMP反应率分别为100%、100%、100%、100%、70%、65%和40%，仅I-IV组与V-VII组之间存在显著差异（P = 0.020，P = 0.008，P = 0.000；P<0.05）。B81-cVEMP的阈值、P13和N23潜伏期与年龄呈正相关（r = 0.756，P = 0.000；r = 0.357，P = 0.003；r = 0.316，P = 0.009；P<0.05）。原始波幅和校正波幅与年龄呈负相关（r = -0.641，P = 0.000；r = -0.609，P = 0.000，P<0.05）。对于B81-oVEMP，校正波幅与年龄呈负相关（r = -0.638，P = 0.000，P<0.05），但阈值和N10潜伏期与年龄呈正相关（r = 0.768，P = 0.000；r = 0.334，P = 0.009，P<0.05）。此外，B81-cVEMP和B81-oVEMP的双耳不对称率与年龄无显著相关性。
随着年龄增长，B81-cVEMP反应率降低，阈值升高，P13和N23潜伏期延长，原始波幅和校正波幅降低。B81-oVEMP反应率和校正波幅降低，阈值升高，N10潜伏期随年龄延长。这些变化可能是由于前庭系统随着衰老发生形态和功能改变所致。因此，我们建议在评估前庭疾病患者的VEMP结果时，根据不同年龄组建立不同的参考值。
