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识别与转座元件相关的表观遗传变化的近期生物信息学进展。

Recent Bioinformatic Progress to Identify Epigenetic Changes Associated to Transposable Elements.

作者信息

Lerat Emmanuelle

机构信息

Univ Lyon, Univ Lyon 1, CNRS, VetAgro Sup, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France.

出版信息

Front Genet. 2022 May 13;13:891194. doi: 10.3389/fgene.2022.891194. eCollection 2022.

Abstract

Transposable elements (TEs) are recognized for their great impact on the functioning and evolution of their host genomes. They are associated to various deleterious effects, which has led to the evolution of regulatory epigenetic mechanisms to control their activity. Despite these negative effects, TEs are also important actors in the evolution of genomes by promoting genetic diversity and new regulatory elements. Consequently, it is important to study the epigenetic modifications associated to TEs especially at a locus-specific level to determine their individual influence on gene functioning. To this aim, this short review presents the current bioinformatic tools to achieve this task.

摘要

转座元件(TEs)因其对宿主基因组功能和进化的巨大影响而被人们所认识。它们与各种有害效应相关联,这导致了调控性表观遗传机制的进化以控制其活性。尽管存在这些负面影响,但TEs通过促进遗传多样性和新的调控元件,在基因组进化中也是重要的参与者。因此,研究与TEs相关的表观遗传修饰,尤其是在基因座特异性水平上,以确定它们对基因功能的个体影响非常重要。为此,这篇简短的综述介绍了目前用于完成这项任务的生物信息学工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0706/9140218/307346412993/fgene-13-891194-g001.jpg

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