Zemleduch Tomasz, Czapla Anna, Kimla Piotr, Kudliński Bartosz
Department of Anesthetics, Intensive Care and Emergency Medicine, Collegium Medicum, University of Zielona Gora, Zyty 28, 65-046, Zielona Gora, Poland.
Collegium Medicum, University of Zielona Gora, Zyty 28, 65-046, Zielona Gora, Poland.
Case Rep Med. 2022 May 18;2022:1424749. doi: 10.1155/2022/1424749. eCollection 2022.
Hypereosinophilic syndrome (HES) is a rare condition characterized by profound peripheral eosinophilia and various organ dysfunction. Diagnostic criteria and classification of this challenging medical entity changed over time. Elevated absolute eosinophil count with extensive tissue infiltration and signs of organ damage of unknown origin is termed idiopathic HES. Hypereosinophilia is a highly hypercoagulable state; thus, a variety of thromboembolic complications may occur. Only a few reports of idiopathic HES patients with different forms of thrombosis are being published. We document a case of a young male presented with persistent abdominal pain with two eosinophilic colon tumors. The patient suffered from phlegmasia cerulea dolens and portal vein thrombosis, followed by pulmonary embolism and overt disseminated intravascular coagulation (DIC). Corticosteroids successfully reduced and controlled eosinophil level while skilled anticoagulation and supportive management overcome DIC-associated complications.
高嗜酸性粒细胞综合征（HES）是一种罕见疾病，其特征为严重的外周嗜酸性粒细胞增多及各种器官功能障碍。这一具有挑战性的医学实体的诊断标准和分类随时间而变化。绝对嗜酸性粒细胞计数升高，伴有广泛的组织浸润和不明原因的器官损伤体征，称为特发性HES。嗜酸性粒细胞增多是一种高度易发生血栓形成的状态；因此，可能会出现各种血栓栓塞并发症。目前仅有少数关于不同形式血栓形成的特发性HES患者的报告发表。我们记录了一例年轻男性病例，该患者因持续性腹痛就诊，发现有两个嗜酸性粒细胞性结肠肿瘤。患者出现了股青肿和门静脉血栓形成，随后发生肺栓塞及明显的弥散性血管内凝血（DIC）。皮质类固醇成功降低并控制了嗜酸性粒细胞水平，同时专业的抗凝和支持治疗克服了与DIC相关的并发症。
