Li Dezhi, Xu Li, Lin Dianjie, Jiang Shujuan, Feng Saran, Zhu Ling
Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Department of Hematology, Shandong Provincial Qianfoshan Hospital, Jinan, China.
Respir Med Case Rep. 2018 Sep 10;25:213-215. doi: 10.1016/j.rmcr.2018.09.006. eCollection 2018.
Acute pulmonary embolism (PE) is a most dangerous complication that needs prompt treatment to reduce potentially death. There are many well-known prognostic factors indicate the morbidity and mortality in various thromboembolic events. Persistent eosinophilia in peripheral blood can lead to tissue infiltration and even organ damage, but the urgent event of thromboembolism in pulmonary provoked by eosinophil eosinophilia in idiopathic hypereosinophilic syndrome (HES) is relative an unusual presentation. In this paper, we present two cases of patients with multiple PE and deep vein thrombosis secondary to the idiopathic HES. Patients were all treated using anticoagulant therapy and corticosteroids successfully. Accordingly, eosinophilia is another risk and precipitating factor of pulmonary thromboembolism. It is necessary for physicians to make a diagnosis in hypereosinophilia as soon as possible for proper prognosis and in case of further thromboembolic events and prevent end-organ damage.
急性肺栓塞（PE）是一种极其危险的并发症，需要及时治疗以降低潜在的死亡风险。有许多众所周知的预后因素可表明各种血栓栓塞事件中的发病率和死亡率。外周血中持续性嗜酸性粒细胞增多可导致组织浸润甚至器官损伤，但特发性嗜酸性粒细胞增多综合征（HES）中嗜酸性粒细胞增多引发的肺部血栓栓塞急症相对较为罕见。在本文中，我们报告了两例继发于特发性HES的多发性PE和深静脉血栓形成的患者。患者均成功接受了抗凝治疗和皮质类固醇治疗。因此，嗜酸性粒细胞增多是肺血栓栓塞的另一个风险和诱发因素。医生有必要尽快诊断嗜酸性粒细胞增多症，以便进行适当的预后评估，并防止进一步的血栓栓塞事件和终末器官损伤。
