Greco Federico, Beomonte Zobel Bruno, Mallio Carlo Augusto
Unità Operativa Complessa Diagnostica per Immagini Territoriale Aziendale, Cittadella della Salute Azienda Sanitaria Locale di Lecce, Lecce 73100, Italy.
Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, Rome 00128, Italy.
World J Radiol. 2022 Apr 28;14(4):82-90. doi: 10.4329/wjr.v14.i4.82.
Sarcopenia is the loss of skeletal muscle mass (SMM) and is a sign of cancer cachexia. Patients with advanced renal cell carcinoma (RCC) may show cachexia.
To evaluate the amount of SMM in male clear cell RCC (ccRCC) patients with and without collateral vessels.
In this study, we included a total of 124 male Caucasian patients divided into two groups: ccRCCa group without collateral vessels ( = 54) and ccRCCp group with collateral vessels ( = 70). Total abdominal muscle area (TAMA) was measured in both groups using a computed tomography imaging-based approach. TAMA measures were also corrected for age in order to rule out age-related effects.
There was a statistically significant difference between the two groups in terms of TAMA ( < 0.05) driven by a reduction in patients with peritumoral collateral vessels. The result was confirmed by repeating the analysis with values corrected for age ( < 0.05), indicating no age effect on our findings.
This study showed a decreased TAMA in ccRCC patients with peritumoral collateral vessels. The presence of peritumoral collateral vessels adjacent to ccRCC might be a fine diagnostic clue to sarcopenia.
肌肉减少症是骨骼肌质量（SMM）的丧失，是癌症恶病质的一个标志。晚期肾细胞癌（RCC）患者可能会出现恶病质。
评估有无侧支血管的男性透明细胞肾细胞癌（ccRCC）患者的SMM量。
在本研究中，我们共纳入了124名男性白种人患者，分为两组：无侧支血管的ccRCCa组（n = 54）和有侧支血管的ccRCCp组（n = 70）。两组均采用基于计算机断层扫描成像的方法测量总腹部肌肉面积（TAMA）。为排除年龄相关影响，TAMA测量值也进行了年龄校正。
两组间TAMA存在统计学显著差异（P < 0.05），这是由肿瘤周围有侧支血管的患者TAMA降低所致。通过对年龄校正后的值重复分析（P < 0.05）证实了该结果，表明年龄对我们的研究结果无影响。
本研究显示肿瘤周围有侧支血管的ccRCC患者TAMA降低。ccRCC旁肿瘤周围侧支血管的存在可能是肌肉减少症的一个良好诊断线索。
