Luo Kun, Huang Wenting, Qiao Liansheng, Zhang Xiaoling, Yan Di, Ning Zhiyu, Ma Chengmei, Dang Honglei, Wang Dong, Guo Hongyan, Xie Lan, Cheng Jing
State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, China.
Acta Pharm Sin B. 2022 May;12(5):2239-2251. doi: 10.1016/j.apsb.2021.11.017. Epub 2021 Nov 18.
The potential medicinal value of Ma bamboo (), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that leaf extract (DLE) reduced fasting blood glucose levels, body weight, and low-density lipoprotein cholesterol with low liver toxicity in / mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways. Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase () and phosphoenolpyruvate carboxykinase 1 () expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor (IGF1R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients.
麻竹是中国最受欢迎且具有重要经济价值的竹种之一，其潜在药用价值一直被低估。在本研究中，我们发现麻竹叶提取物（DLE）可降低空腹血糖水平、体重，并降低低密度脂蛋白胆固醇，且对小鼠肝脏毒性较低。此外，进行了基因表达谱分析，通路富集分析表明DLE影响代谢通路。重要的是，DLE激活了AKT信号通路，并通过下调葡萄糖-6-磷酸酶（G6Pase）和磷酸烯醇式丙酮酸羧激酶1（PEPCK1）的表达来减少葡萄糖生成。此外，网络药理学分析通过靶向胰岛素生长因子1受体（IGF1R）（AKT的上游信号转导器）确定芦丁为DLE中的活性成分。由于其降血糖作用和低毒性，DLE可能被视为2型糖尿病患者的辅助治疗选择。
