and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production AKT activation.

The potential medicinal value of Ma bamboo (), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that leaf extract (DLE) reduced fasting blood glucose levels, body weight, and low-density lipoprotein cholesterol with low liver toxicity in / mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways. Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase () and phosphoenolpyruvate carboxykinase 1 () expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor (IGF1R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients.