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基于纳米颗粒的糖尿病眼部并发症药物递送的最新进展与前景

Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications.

作者信息

Wang Siqi, Yang Hongyu, Zheng Jiaying, Tong Aiyang, Mu Sen, Wang Dongkai, Zhao Ming, Li Ji

机构信息

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, P. R. China.

出版信息

Theranostics. 2025 Feb 25;15(8):3551-3570. doi: 10.7150/thno.108691. eCollection 2025.

DOI:10.7150/thno.108691
PMID:40093887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11905120/
Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being of particular concern due to their severity and impact on quality of life. Hyperglycemia-induced ocular damage often results in a range of lesions, including diabetic retinopathy (DR), keratopathy, cataracts, and glaucoma. These conditions impose considerable physical discomfort on patients and place a substantial economic burden on healthcare systems. The advent of nanotechnology has facilitated the development of innovative therapeutic strategies for managing diabetic ocular complications. This review highlights several common ocular complications associated with DM, focusing on their pathogenesis and treatment strategies. Emphasis is placed on the innovative applications and potential of nanotechnology in treating diabetic ocular complications.

摘要

糖尿病（DM）是一种慢性代谢紊乱疾病，会对多个器官系统产生重大影响。糖尿病的全身影响会导致众多并发症，其中眼部表现因其严重性和对生活质量的影响而备受关注。高血糖引起的眼部损伤通常会导致一系列病变，包括糖尿病视网膜病变（DR）、角膜病、白内障和青光眼。这些病症给患者带来极大的身体不适，并给医疗系统造成沉重的经济负担。纳米技术的出现推动了用于管理糖尿病眼部并发症的创新治疗策略的发展。本综述重点介绍了几种与糖尿病相关的常见眼部并发症，着重阐述其发病机制和治疗策略。重点在于纳米技术在治疗糖尿病眼部并发症方面的创新应用和潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5423/11905120/845b9d8bc202/thnov15p3551g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5423/11905120/74a17851fa61/thnov15p3551g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5423/11905120/845b9d8bc202/thnov15p3551g008.jpg

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引用本文的文献

[1]
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Front Immunol. 2025-8-8

[2]
Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy.

J Nanobiotechnology. 2025-8-20

[3]
From Glucotoxicity to Lung Injury: Emerging Perspectives on Diabetes-Associated Respiratory Complications.

Lung. 2025-7-15

本文引用的文献

[1]
A Multifunctional Nanodrug Co-Delivering VEGF-siRNA and Dexamethasone for Synergistic Therapy in Ocular Neovascular Diseases.

Int J Nanomedicine. 2024

[2]
Metal-phenolic nanoparticles enhance low temperature photothermal therapy for bacterial biofilm in superficial infections.

J Nanobiotechnology. 2024-11-15

[3]
A RuNPs-based multifunctional nanoplatform with excellent dual enzyme-mimic activities for diabetes diagnosis, cancer cell elimination, and in vitro antibacterial.

Talanta. 2025-2-1

[4]
Soluplus-TPGS Mixed Micelles as a Delivery System for Brigatinib: Characterization and In Vitro Evaluation.

ACS Omega. 2024-9-19

[5]
Recent advances in NLRP3 inflammasome in corneal diseases: Preclinical insights and therapeutic implications.

Ocul Surf. 2024-10

[6]
Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation.

Acta Pharm Sin B. 2024-9

[7]
Silica Nanoparticles Decorated with Ceria Quantum Dots Modulate Intra- and Extracellular Reactive Oxygen Species Formation and Selectively Reduce Human A375 Melanoma Cell Proliferation.

ACS Appl Mater Interfaces. 2024-9-25

[8]
Molecular imaging nanoprobes and their applications in atherosclerosis diagnosis.

Theranostics. 2024

[9]
Frequency of Topical Immunomodulatory and Immunosuppressive Therapies for Ocular Chronic Graft-versus-Host Disease.

J Clin Med. 2024-8-12

[10]
Comparative Study of TPGS and Soluplus Polymeric Micelles Embedded in Poloxamer 407 In Situ Gels for Intranasal Administration.

Gels. 2024-8-9

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