RNA mA去甲基化酶的详细综述。
Detailed resume of RNA mA demethylases.
作者信息
Shen Dandan, Wang Bo, Gao Ya, Zhao Lijuan, Bi Yaping, Zhang Jinge, Wang Ning, Kang Huiqin, Pang Jingru, Liu Ying, Pang Luping, Chen Zhe-Sheng, Zheng Yi-Chao, Liu Hong-Min
机构信息
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450052, China.
Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China.
出版信息
Acta Pharm Sin B. 2022 May;12(5):2193-2205. doi: 10.1016/j.apsb.2022.01.003. Epub 2022 Jan 11.
6-Methyladenosine (mA) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, mA modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two mA demethylases have been reported, fat mass and obesity-associated protein (FTO) and alkylation protein AlkB homolog 5 (ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5.
6-甲基腺嘌呤（mA）是真核生物mRNA中最丰富的内部修饰，在各种生物过程中起关键作用。与其他表观遗传修饰一样，mA修饰可由甲基转移酶复合物催化，并动态消除以维持细胞内稳态。到目前为止，仅报道了两种mA去甲基化酶，即脂肪量和肥胖相关蛋白（FTO）和烷基化蛋白AlkB同源物5（ALKBH5），它们参与广泛的mRNA生物学进程，包括mRNA剪接、输出、代谢和稳定性。此外，它们参与许多重要的生物信号通路，并与其他疾病一起促进癌症的进展和发展。在这篇综述中，我们重点关注关于FTO和ALKBH5的结构、抑制剂开发及生物学功能的研究。
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