Generette Gabriela S, Troyer James, Hemenway Alice, Al Zoubi Moamen
Department of Internal Medicine, University of Illinois College of Medicine, Rockford, IL, USA.
College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
IDCases. 2022 May 21;28:e01511. doi: 10.1016/j.idcr.2022.e01511. eCollection 2022.
Since the onset of the COVID-19 pandemic, to date, around 385 million cases have been diagnosed worldwide leading to an estimated 5.7 million death toll. Mass vaccination campaigns have been conducted to control the spread of infection with the most commonly used vaccines being Pfizer-BioNTech and Moderna. However, the adverse effects of vaccination have not yet been fully investigated. Of concern are some serious cardiovascular events such as myocarditis, pericarditis, or perimyocarditis development post-vaccination. Hemorrhagic pericardial effusion has not been reported. However, we report a case of myopericarditis with a hemorrhagic pericardial effusion that developed two weeks following BNT162b2 mRNA COVID-19 vaccination. We performed a complete workup identifying the underlying cause that did not yield any significant findings. Our patient was treated with colchicine and ibuprofen, and he made a full recovery. A follow-up cardiovascular magnetic resonance imaging (CMR) showed no signs of active inflammation.
自新冠疫情爆发以来，截至目前，全球已确诊约3.85亿例病例，估计死亡人数达570万。为控制感染传播，已开展大规模疫苗接种运动，最常用的疫苗是辉瑞-生物科技公司和莫德纳公司生产的疫苗。然而，疫苗的不良反应尚未得到充分研究。令人担忧的是，接种疫苗后会出现一些严重的心血管事件，如心肌炎、心包炎或心肌心包炎。尚未有出血性心包积液的报告。然而，我们报告了一例在接种BNT162b2 mRNA新冠疫苗两周后出现出血性心包积液的心肌心包炎病例。我们进行了全面检查，未发现潜在病因的任何显著结果。我们的患者接受了秋水仙碱和布洛芬治疗，已完全康复。后续的心血管磁共振成像（CMR）未显示有活动性炎症迹象。
