Lu Xin-Yang, Li Jing, Kong Fen-Ying, Wei Mei-Jie, Zhang Pei, Li Ying, Fang Hai-Lin, Wang Wei
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, China.
Front Chem. 2022 May 11;10:892919. doi: 10.3389/fchem.2022.892919. eCollection 2022.
An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide-TiO-Au nanocomposite-modified glassy carbon electrode (rGO-TiO-Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO-TiO-Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO-TiO-Au/GCE for ACV. As a result, rGO-TiO-Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1-100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.
通过使用还原氧化石墨烯-二氧化钛-金纳米复合材料修饰的玻碳电极（rGO-TiO-Au/GCE）设计了一种用于灵敏检测阿昔洛韦（ACV）的电化学传感器。利用透射电子显微镜、X射线衍射仪和X射线光电子能谱来确认rGO-TiO-Au纳米复合材料的形态、结构和组成特性。采用循环伏安法和线性扫描伏安法来证明rGO-TiO-Au/GCE对ACV的分析性能。结果表明，在pH为6.0的PB溶液、开路下80 s的富集时间以及7 μl的修饰剂用量条件下，rGO-TiO-Au/GCE对ACV的氧化表现出最佳响应。ACV的氧化峰电流在1-100 μM范围内随其浓度呈线性增加，计算得出检测限为0.3 μM（S/N = 3）。片剂样品中ACV浓度的测定也显示出令人满意的结果。
