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[大鼠杏仁核基底外侧核损毁后的电生理和行为变化]

[Electrophysiologic and behavioral changes after destruction of the basolateral nucleus of the amygdala in the rat].

作者信息

Sidorov B M, Sosina V D

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Nov-Dec;36(6):1061-8.

PMID:3564682
Abstract

In experiments on rats the influence was studied of unilateral destruction of the basolateral amygdala on heterogeneous conditioned reflexes and focal potentials (FPs) of the dorso-medial thalamic nucleus, elicited by stimulation of the peri-amygdalar cortex. It is shown that reduction during 3-4 postsurgery weeks of the number of goal-directed reactions and increase of their latencies are accompanied by suppression of the evoked activity, testifying to disturbance of functional interaction between the structures of limbic and thalamic levels. Changes of FPs parameters, reflecting the establishment of new functional interrelations between the centres of the lesioned system excelled in duration compensatory restoration of properties of conditioned reflexes.

摘要

在对大鼠的实验中,研究了单侧损毁基底外侧杏仁核对由刺激杏仁核周围皮层所引发的背内侧丘脑核的异质性条件反射和局灶电位(FPs)的影响。结果表明,术后3 - 4周内目标导向反应数量减少及其潜伏期增加的同时,诱发活动受到抑制,这证明了边缘系统和丘脑水平结构之间功能相互作用的紊乱。FPs参数的变化反映了受损系统各中枢之间新功能相互关系的建立,这种变化在条件反射特性的持续代偿性恢复方面表现出色。

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