Albaine-Pons J R, Bogach P G, Chaichenko G M, Makarchuk N E
Acta Neurobiol Exp (Wars). 1980;40(3):625-32.
Bilateral lesions of the basolateral amygdala caused facilitation of instrumental alimentary conditioned reflexes while bilateral cortico-medial amygdala damage produced inhibition of conditioned responses. The most rapid learning was in rats after basolateral lesions whereas the cortico-medial rats required more trials to criterion than controls. In basolateral rats the largest number of intertrial responses were found, while cortico-medial rats had a small number of ITR in criterion sessions. Thus, the cortico-medial amygdala was concerned with the excitatory system and the basolateral amygdala with the inhibitory system of the rat forebrain. The results of combined unilateral lesions of basolateral and cortico-medial amygdala in each hemisphere suggest that in healthy animals the inhibitory influence of the former was stronger and overlapped or regulated the excitatory action of the latter. Our evidence suggests the existence of two antagonistic systems in the rat amygdala which play different roles in conditioning.
基底外侧杏仁核的双侧损伤促进了工具性摄食条件反射，而皮质内侧杏仁核的双侧损伤则抑制了条件反应。学习速度最快的是基底外侧损伤后的大鼠，而皮质内侧损伤的大鼠达到标准所需的试验次数比对照组多。在基底外侧损伤的大鼠中，试验间期反应的数量最多，而皮质内侧损伤的大鼠在达到标准的试验中试验间期反应的数量较少。因此，皮质内侧杏仁核与大鼠前脑的兴奋系统有关，而基底外侧杏仁核与抑制系统有关。每个半球基底外侧和皮质内侧杏仁核联合单侧损伤的结果表明，在健康动物中，前者的抑制作用更强，重叠或调节了后者的兴奋作用。我们的证据表明，大鼠杏仁核中存在两个拮抗系统，它们在条件反射中发挥着不同的作用。
