Komada Munekazu, Nishimura Yuhei
Mammalian Embryology, Department of Life Science, Faculty of Science and Engineering, Kindai University, Osaka, Japan.
Department of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Japan.
Front Cell Dev Biol. 2022 May 12;10:852752. doi: 10.3389/fcell.2022.852752. eCollection 2022.
Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.
神经炎症是自闭症谱系障碍、胎儿酒精综合征和脑瘫等神经发育障碍的一个病因。基础科学和临床科学的多条证据表明，表观遗传格局的失调，包括DNA甲基化和微小RNA（miRNA）表达，与神经炎症相关。遗传和环境因素可影响表观遗传学与神经炎症之间的相互作用，这可能导致神经发育障碍。在这篇小型综述中，我们聚焦于可能由小胶质细胞表观遗传失调介导的神经炎症，并比较使用哺乳动物和斑马鱼的研究。
