Xu Jiping, Li Peng, Zheng Liyan, Chen Qiong
Department of Anesthesiology, Rizhao Central Hospital, Rizhao City, China.
Department of Anesthesiology, Yongkang First People's Hospital, Jinhua City, China.
Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022.
To investigate the anesthetic effect of electro-acupuncture (EA) anesthesia combined with general anesthesia in elderly patients undergoing gastrointestinal tumor resection, and to analyze the effects of EA anesthesia on inflammatory factors, stress state and T lymphocyte subsets in elderly patients.
Total of 118 elderly patients who underwent gastrointestinal tumor resection in our hospital from June 2018 to March 2021 were selected and divided into the control group (59 cases) and the observation group (59 cases) according to the random number method. General anesthesia was adopted in the control group and EA anesthesia combined with general anesthesia was adopted in the observation group. The anesthesia effect, stress state, levels of inflammatory factors, T-lymphocyte subsets and adverse reactions were compared.
The VAS score, agitation score and respiratory normalization time in the observation group were lower than those in the control group ( < 0.05). After surgery, the levels of serum Cor, ET, NE and DA in the observation group were lower than those in the control group ( < 0.05). At 24 h after surgery, the levels of serum TNF-α, IL-6 and IL-1β in the observation group were lower than those in the control group ( < 0.05). At 24 h after surgery, the levels of , , and in the two groups were lower than those before surgery, and the levels of , , and in the observation group were higher than those in the control group ( < 0.05). During the hospitalization, the total incidence rate of adverse reactions after anesthesia in the observation group was lower than that in the control group ( < 0.05).
EA anesthesia combined with general anesthesia has good anesthesia effect when used for gastrointestinal tumor resection in the elderly. It can stabilize the internal environment of patients, alleviate postoperative stress response and inflammatory response, and regulate the body immune function. Moreover, it has high safety and can significantly reduce the occurrence of postoperative adverse reactions.
探讨电针麻醉联合全身麻醉在老年胃肠道肿瘤切除患者中的麻醉效果,并分析电针麻醉对老年患者炎症因子、应激状态及T淋巴细胞亚群的影响。
选取2018年6月至2021年3月在我院行胃肠道肿瘤切除术的118例老年患者,按随机数字法分为对照组(59例)和观察组(59例)。对照组采用全身麻醉,观察组采用电针麻醉联合全身麻醉。比较两组的麻醉效果、应激状态、炎症因子水平、T淋巴细胞亚群及不良反应。
观察组的视觉模拟评分法(VAS)评分、躁动评分及呼吸恢复正常时间均低于对照组(P<0.05)。术后,观察组血清皮质醇(Cor)、内皮素(ET)、去甲肾上腺素(NE)及多巴胺(DA)水平低于对照组(P<0.05)。术后24小时,观察组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-1β(IL-1β)水平低于对照组(P<0.05)。术后24小时,两组CD3⁺、CD4⁺及CD4⁺/CD8⁺水平均低于术前,且观察组CD3⁺、CD4⁺及CD4⁺/CD8⁺水平高于对照组(P<0.05)。住院期间,观察组麻醉后不良反应总发生率低于对照组(P<0.05)。
电针麻醉联合全身麻醉用于老年胃肠道肿瘤切除时麻醉效果良好。它能稳定患者内环境,减轻术后应激反应和炎症反应,调节机体免疫功能。此外,其安全性高,可显著降低术后不良反应的发生。