Chen Xinzhe, Tian Peng-Chao, Wang Kai, Wang Man, Wang Kun
Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Front Cardiovasc Med. 2022 May 11;9:897815. doi: 10.3389/fcvm.2022.897815. eCollection 2022.
Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac function, is the leading cause of death worldwide. The regulation of cardiomyocyte death plays a crucial role in CVD. Previous studies have shown that the modes of cardiomyocyte death include apoptosis and necrosis. However, another new form of death, pyroptosis, plays an important role in CVD pathogenesis. Pyroptosis induces the amplification of inflammatory response, increases myocardial infarct size, and accelerates the occurrence of cardiovascular disease, and the control of cardiomyocyte pyroptosis holds great promise for the treatment of cardiovascular disease. In this paper, we summarized the characteristics, occurrence and regulation mechanism of pyroptosis are reviewed, and also discussed its role and mechanisms in CVD, such as atherosclerosis (AS), myocardial infarction (MI), arrhythmia and cardiac hypertrophy.
心血管疾病（CVD）是一种对人类健康构成巨大威胁的常见疾病。在应激条件下，由于心肌细胞死亡和缺乏再生能力导致的不可逆心脏损伤，最终导致心脏功能受损，是全球范围内的主要死因。心肌细胞死亡的调控在心血管疾病中起着至关重要的作用。先前的研究表明，心肌细胞死亡的模式包括凋亡和坏死。然而，另一种新的死亡形式——细胞焦亡，在心血管疾病发病机制中发挥着重要作用。细胞焦亡诱导炎症反应放大，增加心肌梗死面积，并加速心血管疾病的发生，控制心肌细胞焦亡对心血管疾病的治疗具有很大的前景。在本文中，我们总结了细胞焦亡的特征、发生及调控机制，并讨论了其在动脉粥样硬化（AS）、心肌梗死（MI）、心律失常和心脏肥大等心血管疾病中的作用及机制。
