Pires Da Silva Julie, Casa de Vito Mariana, Miyano Carissa, Sucharov Carmen C
Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
J Cardiovasc Dev Dis. 2025 Jan 25;12(2):42. doi: 10.3390/jcdd12020042.
Mitochondria play a crucial role in multiple cellular processes such as energy metabolism, generation of reactive oxygen species, excitation-contraction coupling, cell survival and death. Dysfunction of mitochondria contributes to the development of cancer; neuromuscular, cardiovascular/congenital heart disease; and metabolic diseases, including diabetes. Mitochondrial dysfunction can result in excessive reactive oxygen species, a decrease in energy production, mitophagy and apoptosis. All these processes are known to be dysregulated in cardiovascular diseases. The focus of this review is to summarize our current knowledge of mitochondrial dysfunction, including mitophagy and apoptosis, in pediatric congenital heart disease due to maternal diabetes or due to structural cardiac defects, with a focus on single-ventricle congenital heart disease. We also discuss recent mitochondria-targeted therapies for cardiovascular diseases.
线粒体在多种细胞过程中发挥着关键作用，如能量代谢、活性氧的产生、兴奋 - 收缩偶联、细胞存活和死亡。线粒体功能障碍会导致癌症、神经肌肉疾病、心血管/先天性心脏病以及包括糖尿病在内的代谢性疾病的发生。线粒体功能障碍可导致活性氧过量、能量产生减少、线粒体自噬和细胞凋亡。众所周知，所有这些过程在心血管疾病中都会失调。本综述的重点是总结我们目前对线粒体功能障碍（包括线粒体自噬和细胞凋亡）在因母亲患糖尿病或因心脏结构缺陷导致的小儿先天性心脏病中的认识，重点关注单心室先天性心脏病。我们还讨论了最近针对心血管疾病的线粒体靶向治疗方法。
