De Colibus Luigi, Stunnenberg Melissa, Geijtenbeek Teunis B H
Department of Experimental Immunology, Amsterdam institute of Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Curr Res Immunol. 2022 May 24;3:100-109. doi: 10.1016/j.crimmu.2022.05.002. eCollection 2022.
The human DEAD-Box Helicase 3 X-Linked (DDX3X) is an ATP-dependent RNA helicase involved in virtually every step of RNA metabolism, ranging from transcription regulation in the nucleus to translation initiation and stress granule (SG) formation, and plays crucial roles in innate immunity, as well as tumorigenesis and viral infections. This review discusses latest advances in DDX3X biology and structure-function relationship, including the implications of the recent DDX3X crystal structure in complex with double stranded RNA for RNA metabolism, DDX3X involvement in the cross-talk between innate immune responses and cell stress adaptation, and the roles of DDX3X in controlling cell fate.
人类X连锁DEAD盒解旋酶3（DDX3X）是一种依赖ATP的RNA解旋酶，几乎参与RNA代谢的每一个步骤，从细胞核中的转录调控到翻译起始和应激颗粒（SG）形成，并且在先天免疫以及肿瘤发生和病毒感染中发挥关键作用。本综述讨论了DDX3X生物学及结构-功能关系的最新进展，包括最近DDX3X与双链RNA复合物的晶体结构对RNA代谢的影响、DDX3X参与先天免疫反应与细胞应激适应之间的相互作用，以及DDX3X在控制细胞命运中的作用。
