Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China; Institute of Neurological Diseases, North Sichuan Medical College, Nanchong, Sichuan, China.
Eur Rev Med Pharmacol Sci. 2022 May;26(10):3656-3663. doi: 10.26355/eurrev_202205_28861.
In recent years, many researchers have taken serum ubiquitin c-terminal hydrolase (Uch-L1) as an indicator of post-traumatic brain injury and associated it with cognitive impairment. Alzheimer's disease is characterized by cognitive impairment and energy metabolism disorders. The purpose of this study was to detect whether serum Uch-L1 is related to cognition and brain energy metabolism in healthy people, and to explore whether it can be used as an early blood marker of Alzheimer's disease.
In this prospective cohort study, adult outpatients from a Grade 3A hospital were recruited. They completed the 18F-FDG-PET/CT examination in the nuclear medicine department and were screened by the Mini Mental State scale (MMSE) and the Montreal Cognitive Assessment scale (MoCA). Blood samples were collected from all outpatients to detect the concentration of serum Uch-L1, and the mean standard uptake value (SUVmean) of energy metabolism in the hippocampus during PET/CT examination was collected.
A total of 37 participants, 14 participants with cognitive impairment (MMSE score < 27) and 23 controls (MMSE score 27-30) were included. There was a significant difference in the SUVmean of the hippocampus between the cognitive impairment group and the normal control group (p < 0.05). There was a significant correlation between the SUVmean of the hippocampus and the total score of MMSE in all participants [r = 0.439, 95% CI: (0.139-0.668), p = 0.007]. There were also significant correlations between serum Uch-L1 and MMSE. Based on the significant differences of demographic variables between groups, we conducted a multivariate linear regression analysis of MMSE cognitive scores based on age (X1), length of education (X2) and SUVmean of hippocampus (X3). The regression equation is as follows: Y = 25.709-0.072 X1 + 0.422 X2 + 0.232 X3.
Brain cognitive ability is closely related to energy metabolism and serum Uch-L1 concentration, so serum Uch-L1 may become a blood marker for extensive screening of dementia in the future. We look forward to the introduction of a more accurate and low-cost method for detecting serum Uch-L1 concentration.
近年来，许多研究人员将血清泛素羧基末端水解酶（Uch-L1）作为创伤后脑损伤的标志物，并将其与认知障碍联系起来。阿尔茨海默病的特征是认知障碍和能量代谢紊乱。本研究旨在检测健康人群血清 Uch-L1 是否与认知和脑能量代谢有关，并探讨其是否可作为阿尔茨海默病的早期血液标志物。
在这项前瞻性队列研究中，我们招募了一家 3A 级医院的成年门诊患者。他们在核医学科完成 18F-FDG-PET/CT 检查，并通过简易精神状态量表（MMSE）和蒙特利尔认知评估量表（MoCA）进行筛查。从所有门诊患者中采集血样以检测血清 Uch-L1 的浓度，并采集 PET/CT 检查期间海马区能量代谢的平均标准摄取值（SUVmean）。
共纳入 37 名参与者，其中 14 名认知障碍患者（MMSE 评分<27）和 23 名对照组（MMSE 评分 27-30）。认知障碍组和正常对照组之间海马区 SUVmean 差异有统计学意义（p<0.05）。所有参与者的海马区 SUVmean 与 MMSE 总分之间存在显著相关性[r=0.439，95%CI：（0.139-0.668），p=0.007]。血清 Uch-L1 与 MMSE 之间也存在显著相关性。基于组间人口统计学变量的显著差异，我们对 MMSE 认知评分进行了基于年龄（X1）、受教育年限（X2）和海马区 SUVmean（X3）的多元线性回归分析。回归方程如下：Y=25.709-0.072X1+0.422X2+0.232X3。
大脑认知能力与能量代谢和血清 Uch-L1 浓度密切相关，因此血清 Uch-L1 可能成为未来广泛筛查痴呆症的血液标志物。我们期待引入一种更准确、低成本的检测血清 Uch-L1 浓度的方法。
