Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD, 21287, USA.
University of Wisconsin School of Medicine and Public Health, 750 Highland Ave, Madison, WI, 53726, USA.
Eur Radiol. 2022 Dec;32(12):8748-8760. doi: 10.1007/s00330-022-08894-1. Epub 2022 Jun 1.
To develop a general framework to assess temporal changes in lesion morphology on radiological images beyond volumetric changes and to test whether cocaine abstinence changes coronary plaque structure on serial coronary CT angiography (CTA).
Chronic cocaine users with human immunodeficiency virus (HIV) infection were prospectively enrolled to undergo cash-based contingency management to achieve cocaine abstinence. Participants underwent coronary CTA at baseline and 6 and 12 months following recruitment. We segmented all coronary plaques and extracted 1103 radiomic features. We implemented weighted correlation network analysis to derive consensus eigen radiomic features (named as different colors) and used linear mixed models and mediation analysis to assess whether cocaine abstinence affects plaque morphology correcting for clinical variables and plaque volumes and whether serum biomarkers causally mediate these changes. Furthermore, we used Bayesian hidden Markov network changepoint analysis to assess the potential rewiring of the radiomic network.
Sixty-nine PLWH (median age 55 IQR: 52-59 years, 19% female) completed the study, of whom 26 achieved total abstinence. Twenty consensus eigen radiomic features were derived. Cocaine abstinence significantly affected the pink and cyan eigen features (-0.04 CI: [-0.06; -0.02], p = 0.0009; 0.03 CI: [0.001; 0.04], p = 0.0017, respectively). These effects were mediated through changes in endothelin-1 levels. In abstinent individuals, we observed significant rewiring of the latent radiomic signature network.
Using our proposed framework, we found 1 year of cocaine abstinence to significantly change specific latent coronary plaque morphological features and rewire the latent morphologic network above and beyond changes in plaque volumes and clinical characteristics.
• We propose a general methodology to decompose the latent morphology of lesions on radiological images using a radiomics-based systems biology approach. • As a proof-of-principle, we show that 1 year of cocaine abstinence results in significant changes in specific latent coronary plaque morphologic features and rewiring of the latent morphologic network above and beyond changes in plaque volumes and clinical characteristics. • We found endothelin-1 levels to mediate these structural changes providing potential pathological pathways warranting further investigation.
开发一种通用框架，以评估影像学上病变形态的时间变化，超越体积变化，并检验可卡因戒断是否会改变连续冠状动脉 CT 血管造影（CTA）的冠状动脉斑块结构。
前瞻性招募慢性可卡因使用者合并人类免疫缺陷病毒（HIV）感染，以进行基于现金的应急管理，以实现可卡因戒断。参与者在招募后 6 个月和 12 个月进行冠状动脉 CTA。我们对所有冠状动脉斑块进行分割，并提取 1103 个放射组学特征。我们实施加权相关网络分析，得出共识特征放射组学特征（命名为不同颜色），并使用线性混合模型和中介分析来评估可卡因戒断是否会影响斑块形态，同时校正临床变量和斑块体积，以及血清生物标志物是否会导致这些变化。此外，我们使用贝叶斯隐马尔可夫网络变点分析来评估放射组学网络的潜在重连。
69 名 PLWH（中位数年龄 55 岁，IQR：52-59 岁，19%女性）完成了研究，其中 26 名患者完全戒断。得出 20 个共识特征放射组学特征。可卡因戒断显著影响粉红色和青色特征（-0.04 CI：[-0.06；-0.02]，p=0.0009；0.03 CI：[0.001；0.04]，p=0.0017）。这些影响是通过内皮素-1 水平的变化介导的。在戒断的个体中，我们观察到潜在放射组学特征网络的显著重连。
使用我们提出的框架，我们发现可卡因戒断 1 年可显著改变特定的潜伏冠状动脉斑块形态特征，并在斑块体积和临床特征变化之上重新连接潜在的形态网络。
• 我们提出了一种使用基于放射组学的系统生物学方法来分解放射图像上潜在病变形态的通用方法。• 作为原理验证，我们表明可卡因戒断 1 年可导致特定潜伏冠状动脉斑块形态特征的显著变化，并重新连接潜在的形态网络，超越斑块体积和临床特征的变化。• 我们发现内皮素-1 水平介导这些结构变化，为进一步研究提供了潜在的病理途径。
