Ahmed Sara, Archambault Philippe, Auger Claudine, Durand Audrey, Fung Joyce, Kehayia Eva, Lamontagne Anouk, Majnemer Annette, Nadeau Sylvie, Pineau Joelle, Ptito Alain, Swaine Bonnie
School of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Lethbridge-Layton-Mackay, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal, Montreal, QC, Canada.
JMIR Res Protoc. 2022 Jun 1;11(6):e12506. doi: 10.2196/12506.
Rapid advances in technologies over the past 10 years have enabled large-scale biomedical and psychosocial rehabilitation research to improve the function and social integration of persons with physical impairments across the lifespan. The Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies (BRILLIANT) in community mobility rehabilitation aims to generate evidence-based research to improve rehabilitation for individuals with acquired brain injury (ABI).
This study aims to (1) identify the factors limiting or enhancing mobility in real-world community environments (public spaces, including the mall, home, and outdoors) and understand their complex interplay in individuals of all ages with ABI and (2) customize community environment mobility training by identifying, on a continuous basis, the specific rehabilitation strategies and interventions that patient subgroups benefit from most. Here, we present the research and technology plan for the BRILLIANT initiative.
A cohort of individuals, adults and children, with ABI (N=1500) will be recruited. Patients will be recruited from the acute care and rehabilitation partner centers within 4 health regions (living labs) and followed throughout the continuum of rehabilitation. Participants will also be recruited from the community. Biomedical, clinician-reported, patient-reported, and brain imaging data will be collected. Theme 1 will implement and evaluate the feasibility of collecting data across BRILLIANT living labs and conduct predictive analyses and artificial intelligence (AI) to identify mobility subgroups. Theme 2 will implement, evaluate, and identify community mobility interventions that optimize outcomes for mobility subgroups of patients with ABI.
The biomedical infrastructure and equipment have been established across the living labs, and development of the clinician- and patient-reported outcome digital solutions is underway. Recruitment is expected to begin in May 2022.
The program will develop and deploy a comprehensive clinical and community-based mobility-monitoring system to evaluate the factors that result in poor mobility, and develop personalized mobility interventions that are optimized for specific patient subgroups. Technology solutions will be designed to support clinicians and patients to deliver cost-effective care and the right intervention to the right person at the right time to optimize long-term functional potential and meaningful participation in the community.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/12506.
在过去10年中，技术的飞速发展使得大规模生物医学和心理社会康复研究得以开展，以改善身体有损伤者在其整个生命周期中的功能和社会融合。社区移动性康复领域的新技术创新生物医学研究与信息学生活实验室（BRILLIANT）旨在开展循证研究，以改善获得性脑损伤（ABI）患者的康复情况。
本研究旨在（1）确定在现实世界社区环境（公共场所，包括商场、家庭和户外）中限制或增强移动性的因素，并了解这些因素在各年龄段ABI患者中的复杂相互作用；（2）通过持续确定患者亚组最受益的具体康复策略和干预措施，定制社区环境移动性训练。在此，我们展示BRILLIANT计划的研究和技术方案。
将招募一组患有ABI的个体，包括成人和儿童（N = 1500）。患者将从4个健康区域（生活实验室）内的急性护理和康复合作中心招募，并在整个康复过程中进行跟踪。参与者也将从社区招募。将收集生物医学、临床医生报告、患者报告和脑成像数据。主题1将实施并评估在BRILLIANT生活实验室收集数据的可行性，并进行预测分析和人工智能（AI）以识别移动性亚组。主题2将实施、评估并确定优化ABI患者移动性亚组结局的社区移动性干预措施。
各生活实验室的生物医学基础设施和设备已经建立，临床医生和患者报告结局数字解决方案的开发正在进行中。预计招募工作将于2022年5月开始。
该项目将开发并部署一个全面的基于临床和社区的移动性监测系统，以评估导致移动性差的因素，并制定针对特定患者亚组优化的个性化移动性干预措施。技术解决方案将旨在支持临床医生和患者在正确的时间为正确的人提供具有成本效益的护理和正确的干预措施，以优化长期功能潜力并实现有意义的社区参与。
国际注册报告识别码（IRRID）：PRR1-10.2196/12506
