Radboud University, Institute for Molecules and Materials, Heijendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
J Phys Chem A. 2022 Jun 16;126(23):3811-3815. doi: 10.1021/acs.jpca.2c02277. Epub 2022 Jun 1.
Structural isomers, such as conformers or tautomers, are of significant importance across chemistry and biology, as they can have different functionalities. In gas-phase experiments using molecular beams, formation of many different isomers cannot be prevented, and their presence significantly complicates the assignment of spectral lines. Current isomer-resolved spectroscopic techniques heavily rely on theoretical calculations or make use of elaborate double-resonance schemes. We show here that isomer-resolved spectroscopy can also be performed using a single tunable laser. In particular, we demonstrate single-color isomer-resolved spectroscopy by utilizing electrostatic deflection to spatially separate the isomers. We show that for 3-aminophenol we can spatially separate the and conformers and use these pure samples to perform high-resolution REMPI spectroscopy, making the assignment of transitions to a particular isomer trivial, without any additional information. This approach allows one to add isomer specificity to any molecular-beam-based experiment.
结构异构体，如构象异构体或互变异构体，在化学和生物学中都具有重要意义，因为它们可能具有不同的功能。在使用分子束的气相实验中，无法防止许多不同异构体的形成，它们的存在极大地增加了谱线分配的复杂性。目前的异构体分辨光谱技术严重依赖于理论计算或使用复杂的双共振方案。我们在这里展示，也可以使用单个可调谐激光来进行异构体分辨光谱。具体来说，我们通过静电偏转来实现单波长异构体分辨光谱，以空间分离异构体。我们证明，对于 3-氨基酚，我们可以将 和 构象异构体进行空间分离，并使用这些纯样品来进行高分辨率 REMPI 光谱学，从而可以将跃迁分配给特定的异构体，而无需任何其他信息。这种方法可以将异构体特异性添加到任何基于分子束的实验中。
