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气相中电子与激光解吸的胸腺嘧啶核苷和鸟嘌呤的相互作用。

Electron interaction with laser-desorbed thymidine and guanine in the gas phase.

作者信息

Parida Debasish, Chen Jiakuan, Schorr Lara, Nguyen Vy T T, Saqib Muhammad, Bayer Andreas, Zappa Fabio, Denifl Stephan

机构信息

Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstrasse 25, 6020 Innsbruck, Austria.

Center for Molecular Biosciences Innsbruck, Universität Innsbruck, Technikerstrasse 25, 6020 Innsbruck, Austria.

出版信息

Eur Phys J D At Mol Opt Phys. 2025;79(6):76. doi: 10.1140/epjd/s10053-025-01023-9. Epub 2025 Jun 30.

DOI:10.1140/epjd/s10053-025-01023-9
PMID:40606181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12208974/
Abstract

ABSTRACT

In the present study we investigated electron attachment to the nucleoside thymidine (Td) and the nucleobase guanine (G) using a laser desorption source to transfer the compounds into the gas phase. Previous studies with Td indicated that the compound is thermally labile and may degrade upon thermal heating in standard molecular beam source. The present negative ion mass spectra for laser-desorbed Td and resistively heated Td share the same most three abundant fragment anions. Among those is the dehydrogenated parent anion (Td-H) which is strongly enhanced for laser-desorbed Td. We also find a considerable change of the fragmentation pattern for less abundant peaks in the mass spectra as well as changed characteristic in the total and mass selected anion efficiency curves of fragment anions. Electron attachment to G proceeds predominantly at electron energies below 3 eV. We ascribe this property to formation of a dipole-bound anion acting as a precursor state for efficient formation of the dehydrogenated anion (G-H). The present results complement previous electron attachment studies with other nucleobases showing that the dehydrogenated parent anion is the most abundant fragment anion for G as well.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1140/epjd/s10053-025-01023-9.

摘要

摘要

在本研究中，我们使用激光解吸源将化合物转移到气相中，研究了电子与核苷胸腺嘧啶（Td）和核碱基鸟嘌呤（G）的附着情况。先前对Td的研究表明，该化合物热不稳定，在标准分子束源中热加热时可能会降解。激光解吸Td和电阻加热Td的负离子质谱图中，最丰富的三个碎片阴离子相同。其中包括脱氢母阴离子（Td-H），对于激光解吸的Td，它会显著增强。我们还发现质谱图中较不丰富峰的碎片模式有相当大的变化，以及碎片阴离子的总阴离子效率曲线和质量选择阴离子效率曲线的特征也发生了变化。电子与G的附着主要在电子能量低于3 eV时发生。我们将此特性归因于偶极束缚阴离子的形成，它作为脱氢阴离子（G-H）高效形成的前体状态。本研究结果补充了先前对其他核碱基的电子附着研究，表明脱氢母阴离子也是G最丰富的碎片阴离子。

补充信息

在线版本包含可在10.1140/epjd/s10053-025-01023-9获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/72d87f047daf/10053_2025_1023_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/321293373293/10053_2025_1023_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/57ab3c2d8521/10053_2025_1023_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/71233bf5bad5/10053_2025_1023_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/623cd1460f0a/10053_2025_1023_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/96d015fbe5e0/10053_2025_1023_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/72d87f047daf/10053_2025_1023_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/321293373293/10053_2025_1023_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/57ab3c2d8521/10053_2025_1023_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/71233bf5bad5/10053_2025_1023_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/623cd1460f0a/10053_2025_1023_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/96d015fbe5e0/10053_2025_1023_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/436b/12208974/72d87f047daf/10053_2025_1023_Fig6_HTML.jpg

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