Wang Ying, Wang Zi-Lu, Ma Wei-Wei, Xu Yun-He
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.
Org Lett. 2022 Jun 10;24(22):4081-4086. doi: 10.1021/acs.orglett.2c01558. Epub 2022 Jun 1.
A copper-catalyzed regioselective Markovnikov 3,4-hydrosilylation of 2-substituted 1,3-dienes has been accomplished. A wide range of 2-substituted 1,3-dienes and trihydrosilanes are compatible under the optimal conditions. The bisphosphine ligand with a rigid backbone provides the Markovnikov 3,4-hydrosilylation product in better yield and selectivity. Besides, the synthetic utilities of the allylsilanes also were demonstrated by their flexible derivatizations.
实现了铜催化的2-取代1,3-二烯的区域选择性马氏3,4-硅氢化反应。在最佳条件下，多种2-取代1,3-二烯和三氢硅烷具有兼容性。具有刚性骨架的双膦配体能够以更高的产率和选择性得到马氏3,4-硅氢化反应产物。此外，烯丙基硅烷的灵活衍生化也展示了其合成效用。
