铜催化的区域选择性和对映选择性烯丙基硅氢化反应。
Copper-Catalyzed Regiodivergent and Enantioselective Hydrosilylation of Allenes.
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.
出版信息
J Am Chem Soc. 2022 Mar 30;144(12):5535-5542. doi: 10.1021/jacs.2c00260. Epub 2022 Mar 17.
PMID:35297616
Abstract
A copper-catalyzed regiodivergent hydrosilylation of a wide range of simple allenes is reported. Linear and branched allylsilanes were formed by judicious choice of solvents. Furthermore, branched allylsilanes were obtained with high enantioselectivity (up to 97% enantiomeric excess) with the aid of a C2-symmetric bisphosphine ligand in the unprecedented asymmetric allene hydrosilylation.
摘要
报道了一种铜催化的简单丙二烯的区域发散性氢化硅烷化反应。通过选择合适的溶剂，可以得到线性和支链型的烯丙基硅烷。此外，在前所未有的不对称丙二烯氢化硅烷化反应中，借助 C2 对称双膦配体，还可以以高对映选择性（高达 97%的对映体过量）得到支链烯丙基硅烷。
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