Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing 210037, China.
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran 141663-4793, Iran.
ACS Biomater Sci Eng. 2022 Jun 13;8(6):2196-2219. doi: 10.1021/acsbiomaterials.1c01436. Epub 2022 Jun 1.
Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials' synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted.
设计能够仿生伤口愈合和皮肤再生的生物材料最近受到了越来越多的关注。一些生物聚合物的行为类似于细胞外基质（ECM），支持生物界面的黏附和内在的细胞相互作用。聚多巴胺（PDA）是一种天然的生物黏附剂和生物活性聚合物，具有很高的化学多功能性，使其成为广泛的生物医学应用的一个令人兴奋的候选者。此外，基于 PDA 及其衍生物的生物材料具有近红外（NIR）吸收、优异的生物相容性、内在的抗氧化活性、抗菌活性和细胞亲和力。PDA 可以通过控制信号转导途径来调节细胞行为。它控制着细胞在生物材料界面处的黏附斑行为。这些特性使得类黑色素的 PDA 成为一种用于伤口愈合和皮肤再生的迷人的生物材料。本文综述了基于 PDA 的生物材料的合成、性质以及与生物实体的相互作用。此外，还强调了 PDA 纳米和微结构作为伤口敷料配方的组成部分的利用。
