State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China.
Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA.
Neuroimage. 2022 Sep;258:119339. doi: 10.1016/j.neuroimage.2022.119339. Epub 2022 May 29.
Tool understanding and use are supported by a dedicated left-lateralized, intrinsically connected network in the human adult brain. To examine this network's phylogenetic and ontogenetic origins, we compared resting-state functional connectivity (rsFC) among regions subserving tool processing in human adults to rsFC among homologous regions in human neonates and macaque monkeys (adolescent and mature). These homologous regions formed an intrinsic network in human neonates, but not in macaques. Network topological patterns were highly similar between human adults and neonates, and significantly less so between humans and macaques. The premotor-parietal rsFC had most significant contribution to the formation of the neonatal tool network. These results suggest that an intrinsic brain network potentially supporting tool processing exists in the human brain prior to individual tool use experiences, and that the premotor-parietal functional connection in particular offers a brain basis for complex tool behaviors specific to humans.
工具的理解和使用依赖于人类大脑中一个专门的、具有内在连接的左侧化网络。为了研究这个网络的系统发生和个体发生起源，我们比较了人类成年人中负责工具处理的区域的静息状态功能连接（rsFC），以及人类新生儿和猕猴（青少年和成熟）中同源区域的 rsFC。这些同源区域在人类新生儿中形成了一个内在网络，但在猕猴中没有。人类成年人和新生儿之间的网络拓扑模式非常相似，而人类和猕猴之间的模式则不那么相似。运动前顶叶的 rsFC 对新生儿工具网络的形成有最重要的贡献。这些结果表明，在个体使用工具经验之前，人类大脑中可能存在一个潜在的支持工具处理的内在网络，特别是运动前顶叶的功能连接为人类特有的复杂工具行为提供了大脑基础。
