Electronics Materials Lab, College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia; College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne 3004, Australia.
Acta Biomater. 2022 Jul 15;147:34-49. doi: 10.1016/j.actbio.2022.05.043. Epub 2022 May 29.
There is a global epidemic of non-healing wounds. Chronic inflammation, overexpression of pro-inflammatory cytokines, oxidative stress and bacterial infection are implicated in delayed wound healing. Natural extracts are a rich source of bioactive molecules called plant secondary metabolites (PSMs) that include terpenes and phenols. These molecules may facilitate wound healing through their antioxidant, anti-inflammatory, and antibacterial activity. After briefly outlining the process of wound healing and how it is compromised in chronic wounds, this review focuses on investigating how PSMs-based polymers may improve wound healing. Best methods for incorporating PSMs into wound dressings are reviewed and critically compared. The exiting body of literature strongly suggests that PSMs-based polymers incorporated into wound dressings could have clinical value in aiding wound healing. STATEMENT OF SIGNIFICANCE: Chronic wounds develop by the persistence of inflammation, oxidative stress and infection. Chronic wounds affect the worldwide population, by reducing quality of life of patients with significant cost to healthcare systems. To help chronic wounds to heal and overcome this burden, materials with anti-inflammatory, antioxidant and antibacterial properties are required. Plant secondary metabolites (PSMs) are volatile materials that have all these properties. PSMs-based polymers can be fabricated by polymerization techniques. The present review provides an overview of the state-of-the-art of the wound healing mechanisms of PSMs. Current developments in the field of PSMs-based polymers are reviewed and their potential use as wound dressings is also covered.
目前存在着非愈合性伤口的全球性流行问题。慢性炎症、促炎细胞因子的过度表达、氧化应激和细菌感染都与伤口愈合延迟有关。天然提取物是生物活性分子的丰富来源，这些生物活性分子被称为植物次生代谢物（PSMs），包括萜类化合物和酚类化合物。这些分子可能通过其抗氧化、抗炎和抗菌活性促进伤口愈合。本文简要概述了伤口愈合的过程以及慢性伤口中如何受到影响，然后重点研究了基于 PSMs 的聚合物如何改善伤口愈合。本文回顾了将 PSMs 纳入伤口敷料的最佳方法，并进行了批判性比较。现有文献强烈表明，将 PSMs 纳入伤口敷料的聚合物可能在辅助伤口愈合方面具有临床价值。
慢性伤口是通过炎症、氧化应激和感染的持续存在而发展的。慢性伤口影响着全世界的人口，使患者的生活质量下降，并给医疗保健系统带来巨大的经济负担。为了帮助慢性伤口愈合并克服这一负担，需要具有抗炎、抗氧化和抗菌特性的材料。植物次生代谢物（PSMs）是具有所有这些特性的挥发性物质。PSMs 基聚合物可以通过聚合技术来制造。本文综述了 PSMs 在伤口愈合机制方面的最新进展。综述了 PSMs 基聚合物领域的最新发展，并探讨了它们作为伤口敷料的潜在用途。
