Yasuda T, Sunami S, Ogura N, Nishioka T, Nakajima H
Acta Paediatr Scand. 1986 Nov;75(6):1042-5. doi: 10.1111/j.1651-2227.1986.tb10340.x.
A case of hypercalcemia in neonatal subcutaneous fat necrosis, which was successfully treated with a low Ca and vitamin D-free formula, is described. Low 1,25(OH)2D and severe calciuria, which were considered to result from hypercalcemia itself as well as parathyroid suppression, were noted during the hypercalcemic phase. The oral Ca load test was repeatedly normal, suggesting that intestinal hyperabsorption of Ca was not a cause of the hypercalcemia. Later recurrence of calciuria without hypercalcemia was noted concomitant with softening of indurated calcified necrotic tissue. In this patient, cerebral infarction on the left side was detected by CT scanning.
本文描述了一例新生儿皮下脂肪坏死伴高钙血症的病例，该病例通过低钙和无维生素D配方奶成功治愈。在高钙血症阶段，发现1,25(OH)₂D水平降低和严重的钙尿症，这被认为是高钙血症本身以及甲状旁腺抑制所致。口服钙负荷试验反复正常，提示肠道对钙的过度吸收不是高钙血症的原因。后来在硬结钙化坏死组织软化的同时，出现了无高钙血症的钙尿症复发。在该患者中，通过CT扫描检测到左侧脑梗死。
