Kunnamo I, Kallio P, Pelkonen P, Viander M
Acta Paediatr Scand. 1986 Nov;75(6):964-9. doi: 10.1111/j.1651-2227.1986.tb10324.x.
Among 283 children in a prospective study of arthritis we found 15 patients with a self-limited serum-sickness-like disease consisting of urticaria or joint erythema and mostly polyarticular arthritis. The mean duration of joint symptoms was 5.9 days. A preceding infection was reported in 12 patients and 12 had received drugs, the therapy starting on average 12.8 days before the onset of joint symptoms. In 9 cases the drug was penicillin. Four patients had recurrent attacks. Circulating immune complexes were detected in the serum of 12 patients, but specific IgE antibodies to penicillin only in 3 patients. The estimated annual incidence of the condition was 4.7/100,000 children under age 16.
在一项针对关节炎的前瞻性研究中的283名儿童里，我们发现15名患者患有自限性血清病样疾病，其症状包括荨麻疹或关节红斑，且大多为多关节性关节炎。关节症状的平均持续时间为5.9天。12名患者报告有前驱感染，12名患者曾接受药物治疗，治疗平均在关节症状出现前12.8天开始。9例中使用的药物为青霉素。4名患者有复发发作。12名患者的血清中检测到循环免疫复合物，但仅3名患者检测到针对青霉素的特异性IgE抗体。该疾病在16岁以下儿童中的估计年发病率为4.7/10万。
