Wallensteen M, Persson B, Dahlquist G
Acta Paediatr Scand. 1987 Jan;76(1):82-6. doi: 10.1111/j.1651-2227.1987.tb10419.x.
The 24 h urinary C-peptide excretion was determined in 137 normal healthy children, 52 girls and 85 boys, 3-15 years of age. No significant difference was found between boys and girls. Median value of urinary C-peptide for boys and girls was 0.24 nmol/kg/24 h with a range of 0.07-0.61 nmol/kg/24 h. Urinary C-peptide correlated positively and significantly with age, weight, height, body surface area and the 24 h urinary creatinine excretion. Since the values of C-peptide excretion were not normally distributed they were log transformed and plotted against body weight. The linear regression and the 95% confidence limits were then calculated. Girls at puberty, 11-15 years of age, had significantly higher C-peptide excretion per kg body weight and per body surface area than younger girls, 3-10 years of age. Boys 13-15 years of age had significantly higher C-peptide excretion per body surface area than younger boys, 5-12 years of age. This indicates that children during the maximal growth spurt have an increased insulin secretion as measured by urinary C-peptide per body surface area.
对137名3至15岁的正常健康儿童进行了24小时尿C肽排泄量测定，其中52名女孩，85名男孩。未发现男孩和女孩之间存在显著差异。男孩和女孩的尿C肽中位数为0.24 nmol/kg/24小时，范围为0.07至0.61 nmol/kg/24小时。尿C肽与年龄、体重、身高、体表面积以及24小时尿肌酐排泄量呈显著正相关。由于C肽排泄值并非正态分布，因此对其进行对数转换，并针对体重进行绘图。然后计算线性回归和95%置信区间。11至15岁青春期女孩每千克体重和每单位体表面积的C肽排泄量显著高于3至10岁的年幼女孩。13至15岁男孩每单位体表面积的C肽排泄量显著高于5至12岁的年幼男孩。这表明，在生长发育高峰期，儿童每单位体表面积的尿C肽所测得的胰岛素分泌增加。
